Evidence map›Paper›PMID 34488119›Full record

ReviewBiomaterials2021

Resolution of inflammation in bone regeneration: From understandings to therapeutic applications.

Hunter Newman, Yuru Vernon Shih, Shyni Varghese

Open access · greenAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Biomaterials, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 142 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
142citing papers in PubMed, 2 pooled it
13.1field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

142 citing papers in PubMed, 2 syntheses or guidelines pooled it, 261 citations in OpenAlex.

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82 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Hunter NewmanDepartment of Mechanical Engineering and Materials Science, Duke University, Durham, NC, 27710, USA.
Yuru Vernon ShihDepartment of Orthopaedic Surgery, Duke University School of Medicine, Durham, NC, 27710, USA.
Shyni VargheseDepartment of Mechanical Engineering and Materials Science, Duke University, Durham, NC, 27710, USA; Department of Orthopaedic Surgery, Duke University School of Medicine, Durham, NC, 27710, USA; Department of Biomedical Engineering, Duke University, Durham, NC, 27710, USA. Electronic address: shyni.varghese@duke.edu.
Duke University · US

Funding

Modulation of local adenosine signaling to attenuate fracture painR01AR079189 · NIAMS · DUKE UNIVERSITY · PI VARGHESE, SHYNI · 2021 to 2025
$2.8M
Adenosine A2B Receptor in Bone Health and OsteoporosisR01AR071552 · NIAMS · DUKE UNIVERSITY · PI VARGHESE, SHYNI · 2017 to 2021
$2.4M
Diversity Supplement -"Bioinspired Synthetic Grafts for Bone Regeneration"R01AR063184 · NIAMS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI VARGHESE, SHYNI · 2013 to 2017
$1.7M
NIAMS NIH HHS R01 AR063184NIAMS NIH HHS R01 AR071552NIAMS NIH HHS R01 AR079189
6 · The paper itself

Abstract

Impaired bone healing occurs in 5-10% of cases following injury, leading to a significant economic and clinical impact. While an inflammatory response upon injury is necessary to facilitate healing, its resolution is critical for bone tissue repair as elevated acute or chronic inflammation is associated with impaired healing in patients and animal models. This process is governed by important crosstalk between immune cells through mediators that contribute to resolution of inflammation in the local healing environment. Approaches modulating the initial inflammatory phase followed by its resolution leads to a pro-regenerative environment for bone regeneration. In this review, we discuss the role of inflammation in bone repair, the negative impact of dysregulated inflammation on bone tissue regeneration, and how timely resolution of inflammation is necessary to achieve normal healing. We will discuss applications of biomaterials to treat large bone defects with a specific focus on resolution of inflammation to modulate the immune environment following bone injury, and their observed functional benefits. We conclude the review by discussing future strategies that could lead to the realization of anti-inflammatory therapeutics for bone tissue repair.

Indexed as

Bone RegenerationInflammationAnimalsBiocompatible MaterialsBone and BonesHumansWound HealingBiocompatible MaterialsBiomaterialsBone healingDrug deliveryImmunomodulationResolution of inflammation

Identifiers

PMID34488119
PMCPMC8545578
OpenAlexW3198340505

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.