Evidence map›Paper›PMID 34488088›Full record

ArticleJournal of affective disorders2021

Time spent in outdoor light is associated with mood, sleep, and circadian rhythm-related outcomes: A cross-sectional and longitudinal study in over 400,000 UK Biobank participants.

Angus C Burns, Richa Saxena, Céline Vetter, Andrew J K Phillips, Jacqueline M Lane, Sean W Cain

Open access · greenAbstract read
In one paragraph

Article in Journal of affective disorders, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 81 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
81citing papers in PubMed, 2 pooled it
9.7field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

81 citing papers in PubMed, 2 syntheses or guidelines pooled it, 170 citations in OpenAlex.

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21 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 2 countries.

Angus C BurnsSchool of Psychological Sciences and Turner Institute for Brain and Mental Health, Monash University, Melbourne, VIC, Australia.
Richa SaxenaDepartment of Anesthesia, Critical Care, and Pain Medicine, Massachusetts General Hospital, Boston, MA USA; Medical and Population Genetics, Broad Institute, Cambridge, MA USA; The Division of Sleep and Circadian Disorders, Brigham and Women's Hospital, Boston, MA USA.
Céline VetterDepartment of Integrative Physiology, University of Colorado Boulder, Boulder, CO, USA.
Andrew J K PhillipsSchool of Psychological Sciences and Turner Institute for Brain and Mental Health, Monash University, Melbourne, VIC, Australia.
Jacqueline M LaneDepartment of Anesthesia, Critical Care, and Pain Medicine, Massachusetts General Hospital, Boston, MA USA; Medical and Population Genetics, Broad Institute, Cambridge, MA USA; The Division of Sleep and Circadian Disorders, Brigham and Women's Hospital, Boston, MA USA.
Sean W CainSchool of Psychological Sciences and Turner Institute for Brain and Mental Health, Monash University, Melbourne, VIC, Australia. Electronic address: sean.cain@monash.edu.
Monash University · AUBrigham and Women's Hospital · USUniversity of Colorado Boulder · US

Funding

Leveraging human genetics to overcome complex diagnostic challenges, evaluation of pan-ancestry polygenic scores to reduce misdiagnosis of narcolepsy and circadian rhythm sleep wake disorders.R01HG012810 · NHGRI · BRIGHAM AND WOMEN'S HOSPITAL · PI Daniel J Gottlieb · 2023 to 2026
$2.6M
Genetic and molecular basis of circadian rhythm disordersK01HL136884 · NHLBI · MASSACHUSETTS GENERAL HOSPITAL · PI LANE, JACQUELINE MARIE · 2018 to 2022
$848k
Medical Research Council MC_PC_17228Medical Research Council MC_QA137853NHGRI NIH HHS R01 HG012810NHLBI NIH HHS K01 HL136884
6 · The paper itself

Abstract

backgroundLight has powerful effects on mood, sleep, and the circadian system. Humans evolved in an environment with a clear distinction between day and night, but our modern environments have blurred this distinction. Negative effects of light exposure at night have been well characterized. The importance of daytime light exposure has been less well characterized. Here we examine the cross-sectional and longitudinal associations of time spent in daytime outdoor light with mood, sleep, and circadian-related outcomes.

methodsParticipants were drawn from the UK Biobank cohort, a large study of UK adults (n = 502,000; 37-73 years old; 54% women).

resultsUK Biobank participants reported spending a median of 2.5 daylight hours (IQR = 1.5-3.5 h) outdoors per day. Each additional hour spent outdoors during the day was associated with lower odds of lifetime major depressive disorder (95% CI OR:0.92-0.98), antidepressant usage (OR:0.92-0.98), less frequent anhedonia (OR:0.93-0.96) and low mood (OR:0.87-0.90), greater happiness (OR:1.41-1.48) and lower neuroticism (incident rate ratio, IRR:0.95-0.96), independent of demographic, lifestyle, and employment covariates. In addition, each hour of daytime light was associated with greater ease of getting up (OR:1.46-1.49), less frequent tiredness (OR:0.80-0.82), fewer insomnia symptoms (OR:0.94-0.97), and earlier chronotype (adjusted odds ratio; OR:0.75-0.77). Auto-Regressive Cross-Lagged (ARCL) models were used to examine the longitudinal association of time spent in outdoor light at baseline with later mood-, sleep- and circadian-related outcomes reported at time point 2. Overall, longitudinal associations support cross-sectional findings, though generally with smaller effect sizes. LIMITATIONS: Future studies that examine the intensity of daytime light exposure at the ocular level are needed.

conclusionsOur findings suggest that low daytime light exposure is an important environmental risk factor for mood, sleep, and circadian-related outcomes.

Indexed as

Circadian RhythmMajor Depressive DisorderAdultAgedBiological Specimen BanksCross-Sectional StudiesFemaleHumansLongitudinal StudiesMaleMiddle AgedSleepUnited KingdomCircadian rhythmsDaylightDepressionMoodNatural lightSleep

Identifiers

PMID34488088
PMCPMC8892387
OpenAlexW3198872032

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.