ArticleEBioMedicine2021
Baseline iron status and presence of anaemia determine the course of systemic Salmonella infection following oral iron supplementation in mice.
Article in EBioMedicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 28 citations in OpenAlex.
- The associations among iron metabolism markers, iron supplementation regimen, and sepsis-induced myocardial injury: a retrospective study.Frontiers in nutrition · 2026Article
- Iron as an immunometabolic signal in infection and inflammation.Frontiers in immunology · 2026Review
- Iron and the immune system.Nature reviews. Immunology · 2025Review
- TIM-3 ameliorates host responses to Salmonella infection by controlling iron driven CD4EBioMedicine · 2025Article
- Iron homeostasis and cytokine responses in Gabonese children with febrile illness.Communications medicine · 2025Article
- The effects of iron deficient and high iron diets on SARS-CoV-2 lung infection and disease.Frontiers in microbiology · 2024Article
- Cellular iron governs the host response to malaria.PLoS pathogens · 2023Article
- Dietary iron regulates intestinal goblet cell function and alleviates Salmonella typhimurium invasion in mice.Science China. Life sciences · 2023Article
- Advances in Ferritin Physiology and Possible Implications in Bacterial Infection.International journal of molecular sciences · 2023Review
- Article
- Severe anaemia, iron deficiency, and susceptibility to invasive bacterial infections.Wellcome open research · 2023Review
- Article
- Availability of Ferritin-Bound Iron to Enterobacteriaceae.International journal of molecular sciences · 2022Article
- Plasma iron controls neutrophil production and function.Science advances · 2022Article
- DMT1 Protects Macrophages fromInternational journal of molecular sciences · 2022Article
- High Affinity Iron Acquisition Systems Facilitate but Are Not Essential for Colonization of Chickens byFrontiers in microbiology · 2022Article
- Airway Epithelial Cells Differentially Adapt Their Iron Metabolism to Infection WithFrontiers in cellular and infection microbiology · 2022Article
- Physiology and Inflammation Driven Pathophysiology of Iron Homeostasis-Mechanistic Insights into Anemia of Inflammation and Its Treatment.Nutrients · 2021Review
- Nifedipine Potentiates Susceptibility ofAntibiotics (Basel, Switzerland) · 2021Article
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Authors and funding
11 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundIron deficiency anaemia (IDA) is a major health concern. However, preventive iron supplementation in regions with high burden of infectious diseases resulted in an increase of infection related morbidity and mortality.
methodsWe fed male C57BL/6N mice with either an iron deficient or an iron adequate diet. Next, they received oral iron supplementation or placebo followed by intraperitoneal infection with Salmonella Typhimurium (S.Tm).
findingsWe found that mice with IDA had a poorer clinical outcome than mice on an iron adequate diet. Interestingly, iron supplementation of IDA mice resulted in higher bacterial burden in organs and shortened survival. Increased transferrin saturation and non-transferrin bound iron in the circulation together with low expression of ferroportin facilitated the access of the pathogen to iron and promoted bacterial growth. Anaemia, independent of iron supplementation, was correlated with reduced neutrophil counts and cytotoxic T cells. With iron supplementation, anaemia additionally correlated with increased splenic levels of the cytokine IL-10, which is suggestive for a weakened immune control to S.Tm infection.
interpretationSupplementing iron to anaemic mice worsens the clinical course of bacterial infection. This can be traced back to increased iron delivery to bacteria along with an impaired anti-microbial immune response. Our findings may have important implications for iron supplementation strategies in areas with high endemic burden of infections, putting those individuals, who potentially profit most from iron supplementation for anaemia, at the highest risk for infections.
fundingFinancial support by the Christian Doppler Laboratory for Iron Metabolism and Anemia Research.
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