Evidence map›Paper›PMID 34488003›Full record

ReviewCurrent opinion in virology2021

Know your enemy and know yourself - the case of SARS-CoV-2 host factors.

Wai Suet Lee, Meisam Yousefi, Biaoguo Yan, Cythia Lingli Yong, Yaw Shin Ooi

Abstract readReview
In one paragraph

Review in Current opinion in virology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Review
  2. Article
  3. Review
  4. Article
  5. Article
  6. Review
  7. Editorial overview: Viral pathogenesis.Current opinion in virology · 2022
    Article
  8. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Wai Suet LeeProgramme in Emerging Infectious Diseases, Duke-NUS Medical School, Singapore 169857, Singapore.
Meisam YousefiProgramme in Emerging Infectious Diseases, Duke-NUS Medical School, Singapore 169857, Singapore.
Biaoguo YanProgramme in Emerging Infectious Diseases, Duke-NUS Medical School, Singapore 169857, Singapore.
Cythia Lingli YongProgramme in Emerging Infectious Diseases, Duke-NUS Medical School, Singapore 169857, Singapore.
Yaw Shin OoiProgramme in Emerging Infectious Diseases, Duke-NUS Medical School, Singapore 169857, Singapore. Electronic address: yawshin.ooi@duke-nus.edu.sg.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2), the etiologic agent that causes Coronavirus Disease 2019 (COVID-19) pandemic, is a newly emerging respiratory RNA virus with exceptional transmissibility and pathogenicity. Numerous COVID-19 related studies have been fast-tracked, with the ultimate goal to end the pandemic. Here we review the major stages of SARS-CoV-2 infection cycle in cells, with specific emphasis on essential host factors. Insights into the cell biology of SARS-CoV-2 infection have accelerated the development of host-directed therapeutics, as shown by dozens of clinical trials evaluating COVID-19 treatments using host-targeting compounds.

Indexed as

Cathepsin LCOVID-19COVID-19 Drug TreatmentHumansRNA, ViralSARS-CoV-2Virus AssemblyVirus InternalizationCathepsin LRNA, Viral

Identifiers

PMID34488003
PMCPMC8379091

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.