Evidence map›Paper›PMID 34487742›Full record

ReviewSurvey of ophthalmology

Electrical devices for visual restoration.

Tamara Sharf, Tej Kalakuntla, Darrin J Lee, Kimberly K Gokoffski

Open access · greenAbstract readReview
In one paragraph

Review in Survey of ophthalmology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
0.4field-weighted citation impact, top 46% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 10 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Tamara SharfKeck School of Medicine, University of Southern California, CA, USA.
Tej KalakuntlaKeck School of Medicine, University of Southern California, CA, USA.
Darrin J LeeDepartment of Neurological Surgery, University of Southern California, CA, USA.
Kimberly K GokoffskiDepartment of Ophthalmology, Roski Eye Institute, University of Southern California, CA, USA. Electronic address: Kimberly.gokoffski@med.usc.edu.
University of Southern California · US

Funding

Septohippocampal circuit deep brain stimulation for selective RDoC aspects of cognitionK08MH121757 · NIMH · UNIVERSITY OF SOUTHERN CALIFORNIA · PI LEE, DARRIN JASON · 2020 to 2024
$982k
In vivo Application of Electrical Fields Directs Retinal Ganglion Cell Axon RegenerationK08EY031797 · NEI · UNIVERSITY OF SOUTHERN CALIFORNIA · PI GOKOFFSKI, KIMBERLY K · 2020 to 2023
$862k
NEI NIH HHS K08 EY031797NIMH NIH HHS K08 MH121757
6 · The paper itself

Abstract

Given the rising number of patients with blindness from macular, optic nerve, and visual pathway disease, there is considerable interest in the potential of electrical stimulation devices to restore vision. Electrical devices for restoration of visual function can be grouped into three categories: (1) visual prostheses whose goal is to bypass damaged areas and directly activate downstream intact portions of the visual pathway; (2) electric field stimulation whose goal is to activate endogenous transcriptional and molecular signaling pathways to promote neuroprotection and neuro-regeneration; and (3) neuromodulation whose stimulation would resuscitate neural circuits vital to coordinating responses to visual input.  In this review, we discuss these three approaches, describe advances made in the different fields, and comment on limitations and potential future directions.

Indexed as

BlindnessElectric Stimulation TherapyVisual ProsthesisHumansaxon regenerationelectrical stimulationneuromodulationvision restorationvisual prosthesis

Identifiers

PMID34487742
PMCPMC9241872
OpenAlexW3196664050

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.