ArticlePlant biotechnology journal2022
The wheat AGL6-like MADS-box gene is a master regulator for floral organ identity and a target for spikelet meristem development manipulation.
Article in Plant biotechnology journal, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 52 papers.
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52 citing papers in PubMed, 84 citations in OpenAlex.
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- Cysteine-rich receptor-like kinase and MADS-box co-regulation of programmed cell death drives apical spikelet degeneration in wheat.Plant physiology · 2026Article
- Dynamics of H3K4me3 and H3K36me3 histone modifications in response to powdery mildew infection in common wheat.BMC plant biology · 2026Article
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- A regulatory network underlying glume hardness revealed by transcriptomic analysis of an ems-induced mutant in synthetic hexaploid wheat.BMC genomics · 2026Article
- TaAGL6-B1 identified as a candidate gene for the dominant awn-inhibitor locus B2 in wheat.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2026Article
- Spatial transcriptomics reveals expression gradients in developing wheat inflorescences at cellular resolution.The Plant cell · 2026Article
- DArTseq molecular markers associated with water stress tolerance and size reduction in citrandarins rootstocks.Frontiers in plant science · 2026Article
- Loss of function of chromatin remodeler OsCLSY4 leads to RdDM-mediated mis-expression of endosperm-specific genes affecting grain qualities.PLoS genetics · 2025Article
- QSNS.sicau-D12-3B: A novel and major validated QTL governing wheat spikelet number with significant breeding potential.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2025Article
- The transcriptome analysis reveals the regulatory mechanisms of female sterility in Lagerstroemia speciosa 'Zichan'.BMC plant biology · 2025Article
- Antagonistic effects of selection on alleles associated with seed size and seed dormancy in wheat.Genome biology · 2025Article
- VULGARE ROW-TYPE SIX 5 binds to the promoter of tillering and floral homeotic genes to regulate their expression.Plant physiology · 2025Article
- QTL-Seq and Fine-Mapping Analyses Identify QTL and Candidate Genes Controlling Snake-like Pod Surface Trait in Vegetable Cowpea Yardlong Bean.Plants (Basel, Switzerland) · 2025Article
- QTL analysis of spike traits and KASP marker validation for basal sterile spikelet number in wheat.BMC plant biology · 2025Article
- Article
- Genome-wide characterization of the MADS-box gene family in Paeonia ostii and expression analysis of genes related to floral organ development.BMC genomics · 2025Article
- Cloning and functional analysis of ZmMADS42 gene in maize.GM crops & food · 2024Article
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Authors and funding
18 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The AGAMOUS-LIKE6 (AGL6)-like genes are ancient MADS-box genes and are functionally studied in a few model plants. The knowledge of these genes in wheat remains limited. Here, by studying a 'double homoeolog mutant' of the AGL6 gene in tetraploid wheat, we showed that AGL6 was required for the development of all four whorls of floral organs with dosage-dependent effect on floret fertility. Yeast two-hybrid analyses detected interactions of AGL6 with all classes of MADS-box proteins in the ABCDE model for floral organ development. AGL6 was found to interact with several additional proteins, including the G protein β and γ (DEP1) subunits. Analysis of the DEP1-B mutant showed a significant reduction in spikelet number per spike in tetraploid wheat, while overexpression of AGL6 in common wheat increased the spikelet number per spike and hence the grain number per spike. RNA-seq analysis identified the regulation of several meristem activity genes by AGL6, such as FUL2 and TaMADS55. Our work therefore extensively updated the wheat ABCDE model and proposed an alternative approach to improve wheat grain yield by manipulating the AGL6 gene.
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