Evidence map›Paper›PMID 34487577›Full record

ArticleNeurourology and urodynamics2021

A new 3D stress MRI measurement strategy to quantify surgical correction of prolapse in three support systems.

Luyun Chen, Carolyn W Swenson, Bing Xie, James A Ashton-Miller, John O DeLancey

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neurourology and urodynamics, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.7field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 6 citations in OpenAlex.

  1. Chapter 4.5: New Proposed Treatments for Pelvic Organ Prolapse.International urogynecology journal · 2026
    Review
  2. [Application of Magnetic Resonance Imaging in the Diagnosis and Treatment of Middle Compartment Defect].Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition · 2025
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Luyun ChenDepartment of Biomedical Engineering, University of Michigan, Ann Arbor, Michigan, USA.ORCID 0000-0001-6861-180X
Carolyn W SwensonDepartment of Obstetrics and Gynecology, University of Michigan, Ann Arbor, Michigan, USA.ORCID 0000-0002-3220-9445
Bing XieDepartment of Obstetrics and Gynecology, University of Michigan, Ann Arbor, Michigan, USA.
James A Ashton-MillerDepartment of Biomedical Engineering, University of Michigan, Ann Arbor, Michigan, USA.ORCID 0000-0003-1528-2787
John O DeLanceyDepartment of Obstetrics and Gynecology, University of Michigan, Ann Arbor, Michigan, USA.ORCID 0000-0002-1012-7713
University of Michigan · US

Funding

University of Michigan WRHR Career Development ProgramK12HD065257 · NICHD · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI FENNER, DEE ELLEN · 2010 to 2019
$3.4M
Using a mechanistic classification scheme to identify the causes of anterior vaginal wall prolapse and develop a validated surgical planning systemR01HD094954 · NICHD · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI CHEN, LUYUN · 2018 to 2020
$935k
NICHD NIH HHS K12 HD065257NICHD NIH HHS R01 HD094954NIH HHS R01 HD094954
6 · The paper itself

Abstract

aimsThe aim of this study was to develop and test the feasibility of a magnetic resonance imaging (MRI)-based measurement strategy to evaluate the effectiveness of surgical procedures in restoring normal anatomy in all three systems of pelvic floor support and quantify the structural changes induced by prolapse surgery.

methodsPatients underwent clinical examination and stress MRI preoperatively and again 3 months postoperatively. Preoperative and postoperative measures of three MRI-based structural support systems were made: (1) vaginal wall, (2) apical and paravaginal support, and (3) hiatal closure system. Preoperative to postoperative structural changes were calculated and compared to normal values, and bivariate associations were determined.

resultsThe three structural support systems were successfully quantified for both preoperative and postoperative MRIs regardless of operative approaches in all 15 women in the pilot group. Apical support was restored to normal in 11 of 12 patients who underwent an apical suspension procedure and 9 of 14 patients with a posterior repair had normalization of genital hiatus size. Mid-vaginal paravaginal location was elevated an average of 2.5 ± 2.0 cm despite no paravaginal repairs being performed. Paravaginal location improvements were also significantly correlated with apical elevation (r values 0.99-0.87, p < 0.001).

conclusionsA strategy that quantifies structural-specific preoperative impairments and improvements after prolapse surgery was successfully developed. Early findings reveal that prolapse surgery is more successful in restoring normal anatomy at Level I than Level III. Improvement in paravaginal location is significantly correlated with apical elevation.

Indexed as

Pelvic Organ ProlapsePlastic Surgery ProceduresFemaleGynecologic Surgical ProceduresHumansMagnetic Resonance ImagingPelvic FloorProlapseTreatment OutcomeVaginameasurementMRIparavaginal defectpelvic organ prolapsestructure-specificsurgerysurgical correction

Identifiers

PMID34487577
PMCPMC8579275
OpenAlexW3196851250

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.