Evidence map›Paper›PMID 34487373›Full record

ArticleJournal of medical virology2022

Should a third booster dose be scheduled after two doses of CoronaVac? A single-center experience.

Metin Yigit, Aslinur Ozkaya-Parlakay, Yasemin Cosgun, Yunus E Ince, Yunus E Bulut, Emrah Senel

Abstract read
In one paragraph

Article in Journal of medical virology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Review
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Metin YigitDepartment of Pediatrics, Ankara City Hospital, Ankara, Turkey.ORCID 0000-0003-3536-4456
Aslinur Ozkaya-ParlakayDivision of Pediatric Infectious Disease, Department of Pediatrics, Ankara City Hospital, Yildirim Beyazit University, Ankara, Turkey.
Yasemin CosgunMicrobiology Reference Laboratories Department, National Arboviruses and Viral Zoonotic Diseases Laboratory, Public Health General Directorate of Turkey, Ankara, Turkey.ORCID 0000-0002-3815-8036
Yunus E InceDepartment of Pediatrics, Ankara City Hospital, Ankara, Turkey.
Yunus E BulutPublic Health Directorate of Ankara, Ankara, Turkey.
Emrah SenelDepartment of Pediatric Surgery, Ankara City Hospital, Yildirim Beyazit University, Ankara, Turkey.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In the 10th month of the pandemic, coronavirus disease 2019 (COVID-19) vaccination was given first to healthcare workers in Turkey after receiving emergency use approval from the Ministry of Health. This study, which was performed at the COVID-19 reference center in Ankara (the capital of Turkey) aimed to evaluate the seroconversion rate of the CoronaVac vaccine. The anti-spike immunoglobulin G response to the two-dose vaccination was retrospectively examined in healthcare workers who had no previous history of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. The postvaccine seroconversion rate was investigated by measuring the antibody levels of healthcare workers who had received CoronaVac. Vaccination was administered as 600 SU in 28-day intervals. The healthcare workers' anti-SARS-CoV-2 immunoglobulin G levels were used to determine the seroconversion rate 2 months after the second dose of the vaccine. Of the healthcare workers, 22.9% (n = 155) were seronegative. The younger the age of the participant, the higher the level of anti-SARS-CoV-2 immunoglobulin G. Furthermore, anti-SARS-CoV-2 immunoglobulin G levels were much higher in women than men.

Indexed as

AdultAgedAntibodies, NeutralizingAntibodies, ViralCoronavirus Nucleocapsid ProteinsCOVID-19COVID-19 VaccinesFemaleHealth PersonnelHumansImmunization ScheduleImmunization, SecondaryImmunoglobulin GMaleMiddle AgedPhosphoproteinsAntibodies, NeutralizingAntibodies, ViralCoronavirus Nucleocapsid ProteinsCOVID-19 VaccinesImmunoglobulin Gnucleocapsid phosphoprotein, SARS-CoV-2PhosphoproteinsVaccines, InactivatedVaccines, Syntheticbooster doseCOVID-19inactivated vaccine

Identifiers

PMID34487373
PMCPMC8661641

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.