Evidence map›Paper›PMID 34487306›Full record

Observational studyInfection2022

A bacteraemia risk prediction model: development and validation in an emergency medicine population.

Agustín Julián-Jiménez, Juan González Del Castillo, Eric Jorge García-Lamberechts, Itziar Huarte Sanz, Carmen Navarro Bustos, Rafael Rubio Díaz, Josep María Guardiola Tey, Ferrán Llopis-Roca, Pascual Piñera Salmerón, Mikel de Martín-Ortiz de Zarate and 17 more

Abstract readMulticenter StudyObservational Study
PubMed Publisher
In one paragraph

Observational study in Infection, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. [Diagnostic accuracy of procalcitonin for bacteremia in the emergency department: a systematic review].Revista espanola de quimioterapia : publicacion oficial de la Sociedad Espanola de Quimioterapia · 2024
    Pooled it
  2. Article
  3. Article
  4. Article
  5. [Usefulness of the MPB-INFURG-SEMES model to predict bacteremia in the patient with solid tumor in the Emergency Department].Revista espanola de quimioterapia : publicacion oficial de la Sociedad Espanola de Quimioterapia · 2024
    Observational
  6. Observational
  7. Article
  8. [Ability of qSOFA1-lactate to predict 30-day mortality in patients seen for infection in the Emergency Department].Revista espanola de quimioterapia : publicacion oficial de la Sociedad Espanola de Quimioterapia · 2023
    Observational
  9. [Improved profitability and indications for blood culture extraction in emergency departments: another step forward].Revista espanola de quimioterapia : publicacion oficial de la Sociedad Espanola de Quimioterapia · 2023
    Article
  10. Models for bacteraemia risk prediction. Clinical implications.Revista espanola de quimioterapia : publicacion oficial de la Sociedad Espanola de Quimioterapia · 2022
    Review
  11. [New predictive models of bacteremia in the emergency department: a step forward].Revista espanola de quimioterapia : publicacion oficial de la Sociedad Espanola de Quimioterapia · 2022
    Review
  12. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

27 authors.

Agustín Julián-JiménezEmergency Department, Complejo Hospitalario Universitario de Toledo, Universidad de Castilla La Mancha, Toledo, Spain.
Juan González Del CastilloEmergency Department, Hospital Universitario Clínico San Carlos, Calle Profesor Martín Lagos Calle Profesor Martín Lagos, 28040, Madrid, Spain. jgonzalezcast@gmail.com.
Eric Jorge García-LamberechtsEmergency Department, Hospital Universitario Clínico San Carlos, Calle Profesor Martín Lagos Calle Profesor Martín Lagos, 28040, Madrid, Spain.
Itziar Huarte SanzEmergency Department, Hospital Universitario de Donostia, San Sebastian, Spain.
Carmen Navarro BustosEmergency Department, Hospital Universitario Virgen de La Macarena, Sevilla, Spain.
Rafael Rubio DíazEmergency Department, Complejo Hospitalario Universitario de Toledo, Universidad de Castilla La Mancha, Toledo, Spain.
Josep María Guardiola TeyEmergency Department, Hospital Universitario Sant Pau, Barcelona, Spain.
Ferrán Llopis-RocaEmergency Department, Hospital Universitario de Bellvitge, Barcelona, Spain.
Pascual Piñera SalmerónEmergency Department, Hospital Universitario Reina Sofía, Murcia, Spain.
Mikel de Martín-Ortiz de ZarateEmergency Department, Hospital Universitario de Basurto, Bilbao, Spain.
Jesús Álvarez-ManzanaresEmergency Department, Hospital Universitario Rio Hortega, Valladolid, Spain.
Julio Javier Gamazo-Del RioEmergency Department, Hospital Universitario de Galdakao-Usansolo, Bizkaia, Spain.
Marta Álvarez AlonsoEmergency Department, Hospital Universitario de Fuenlabrada, Fuenlabrada, Spain.
Begoña Mora OrdoñezEmergency Department, Hospital Virgen de La Victoria, Málaga, Spain.
Oscar Álvarez LópezEmergency Department, Hospital Universitario de Móstoles, Madrid, Spain.
María Del Mar Ortega RomeroEmergency Department, Hospital Clínic, Barcelona, Spain.
María Del Mar Sousa ReviriegoEmergency Department, Hospital Nuestra Señora del Prado, Talavera de La Reina, Spain.
Ramón Perales PardoEmergency Department, Complejo Hospitalario Universitario de Albacete, Albacete, Spain.
Henrique Villena García Del RealEmergency Department, Complejo Hospitalario Universitario de Santiago de Compostela, Santiago de Compostela , Spain.
María José Marchena GonzálezEmergency Department, Hospital Juan Ramón Jiménez de Huelva, Huelva, Spain.
José María Ferreras AmezEmergency Department, Hospital Clínico Universitario Lozano Blesa de Zaragoza, Zaragoza, Spain.
Félix González MartínezEmergency Department, Hospital Virgen de La Luz de Cuenca, Cuenca, Spain.
Francisco Javier Martín-SánchezEmergency Department, Hospital Universitario Clínico San Carlos, Calle Profesor Martín Lagos Calle Profesor Martín Lagos, 28040, Madrid, Spain.
Pedro Beneyto MartínResearch Unit, Complejo Hospitalario Universitario de Toledo, Toledo, Spain.
Francisco Javier Candel GonzálezClinical Microbiology Department, Hospital Universitario Clínico San Carlos, Madrid, Spain.
Antonio Jesús Díaz-HonrubiaBiomedical Technology Center - E.T.S. of Computer Engineers, Universidad Politécnica de Madrid, Madrid, Spain.
INFURG-SEMES investigators

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveDesign a risk model to predict bacteraemia in patients attended in emergency departments (ED) for an episode of infection.

methodsThis was a national, prospective, multicentre, observational cohort study of blood cultures (BC) collected from adult patients (≥ 18 years) attended in 71 Spanish EDs from October 1 2019 to March 31, 2020. Variables with a p value < 0.05 were introduced in the univariate analysis together with those of clinical significance. The final selection of variables for the scoring scale was made by logistic regression with selection by introduction. The results obtained were internally validated by dividing the sample in a derivation and a validation cohort.

resultsA total of 4,439 infectious episodes were included. Of these, 899 (20.25%) were considered as true bacteraemia. A predictive model for bacteraemia was defined with seven variables according to the Bacteraemia Prediction Model of the INFURG-SEMES group (MPB-INFURG-SEMES). The model achieved an area under the curve-receiver operating curve of 0.924 (CI 95%:0.914-0.934) in the derivation cohort, and 0.926 (CI 95%: 0.910-0.942) in the validation cohort. Patients were then split into ten risk categories, and had the following rates of risk: 0.2%(0 points), 0.4%(1 point), 0.9%(2 points), 1.8%(3 points), 4.7%(4 points), 19.1% (5 points), 39.1% (6 points), 56.8% (7 points), 71.1% (8 points), 82.7% (9 points) and 90.1% (10 points). Findings were similar in the validation cohort. The cut-off point of five points provided the best precision with a sensitivity of 95.94%, specificity of 76.28%, positive predictive value of 53.63% and negative predictive value of 98.50%.

conclusionThe MPB-INFURG-SEMES model may be useful for the stratification of risk of bacteraemia in adult patients with infection in EDs, together with clinical judgement and other variables independent of the process and the patient.

Indexed as

BacteremiaEmergency MedicineAdultBlood CultureEmergency Service, HospitalHumansPredictive Value of TestsProspective StudiesBacteraemiaBlood culturesClinical prediction ruleEmergency health servicesPredictorsProcalcitoninRisk score

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.