Evidence map›Paper›PMID 34487299›Full record

ReviewInternational microbiology : the official journal of the Spanish Society for Microbiology2021

Digging into the lesser-known aspects of CRISPR biology.

Noemí M Guzmán, Belén Esquerra-Ruvira, Francisco J M Mojica

Open access · hybridAbstract readReview
In one paragraph

Review in International microbiology : the official journal of the Spanish Society for Microbiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.1field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 17 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Article
  6. Article
  7. Article
  8. Review
  9. Review
  10. CRISPR meets caspase.Nature microbiology · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Noemí M GuzmánDpto. Fisiología, Genética y Microbiología, Universidad de Alicante, Alicante, Spain.ORCID http://orcid.org/0000-0002-3789-2095
Belén Esquerra-RuviraDpto. Fisiología, Genética y Microbiología, Universidad de Alicante, Alicante, Spain.
Francisco J M MojicaDpto. Fisiología, Genética y Microbiología, Universidad de Alicante, Alicante, Spain. fmojica@ua.es.ORCID http://orcid.org/0000-0002-6660-4996
University of Alicante · ES

Funding

conselleria d'educació, investigació, cultura i esport PROMETEO/2017/129
6 · The paper itself

Abstract

A long time has passed since regularly interspaced DNA repeats were discovered in prokaryotes. Today, those enigmatic repetitive elements termed clustered regularly interspaced short palindromic repeats (CRISPR) are acknowledged as an emblematic part of multicomponent CRISPR-Cas (CRISPR associated) systems. These systems are involved in a variety of roles in bacteria and archaea, notably, that of conferring protection against transmissible genetic elements through an adaptive immune-like response. This review summarises the present knowledge on the diversity, molecular mechanisms and biology of CRISPR-Cas. We pay special attention to the most recent findings related to the determinants and consequences of CRISPR-Cas activity. Research on the basic features of these systems illustrates how instrumental the study of prokaryotes is for understanding biology in general, ultimately providing valuable tools for diverse fields and fuelling research beyond the mainstream.

Indexed as

ArchaeaCRISPR-Cas SystemsBacteriaBiologyAdaptive immunityCas proteinsCRISPRCRISPR regulationNon-canonical CRISPR rolesRNA-guided transposition

Identifiers

PMID34487299
PMCPMC8616872
OpenAlexW3196523078

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.