Evidence map›Paper›PMID 34487227›Full record

ReviewRadiation and environmental biophysics2021

Cancer risk from chronic exposures to chemicals and radiation: a comparison of the toxicological reference value with the radiation detriment.

Enora Cléro, Michèle Bisson, Velly Nathalie, Eric Blanchardon, Eric Thybaud, Yann Billarand

Erratum issuedAbstract readReview
PubMed Publisher
In one paragraph

Review in Radiation and environmental biophysics, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Risk-Reducing Measures for Cancer Prevention.Korean journal of family medicine · 2023
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors.

Enora CléroHealth and Environment Division, Institute for Radiological Protection and Nuclear Safety (IRSN), BP 17, 92262, Fontenay-aux-Roses Cedex, France.
Michèle BissonChronic Risks Division, French National Institute for Industrial Environment and Risks (INERIS), Parc technologique Alata - BP 2, 60550 , Verneuil-en-Halatte, France.
Velly NathalieChronic Risks Division, French National Institute for Industrial Environment and Risks (INERIS), Parc technologique Alata - BP 2, 60550 , Verneuil-en-Halatte, France.
Eric BlanchardonHealth and Environment Division, Institute for Radiological Protection and Nuclear Safety (IRSN), BP 17, 92262, Fontenay-aux-Roses Cedex, France.
Eric ThybaudChronic Risks Division, French National Institute for Industrial Environment and Risks (INERIS), Parc technologique Alata - BP 2, 60550 , Verneuil-en-Halatte, France.
Yann BillarandHealth and Environment Division, Institute for Radiological Protection and Nuclear Safety (IRSN), BP 17, 92262, Fontenay-aux-Roses Cedex, France. yann.billarand@irsn.fr.ORCID 0000-0001-5306-1497

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This article aims at comparing reference methods for the assessment of cancer risk from exposure to genotoxic carcinogen chemical substances and to ionizing radiation. For chemicals, cancer potency is expressed as a toxicological reference value (TRV) based on the most sensitive type of cancer generally observed in animal experiments of oral or inhalation exposure. A dose-response curve is established by modelling experimental data adjusted to apply to human exposure. This leads to a point of departure from which the TRV is derived as the slope of a linear extrapolation to zero dose. Human lifetime cancer risk can then be assessed as the product of dose by TRV and it is generally considered to be tolerable in a 10

Indexed as

NeoplasmsNeoplasms, Radiation-InducedRadiation ExposureAnimalsHumansInhalation ExposureRadiation DosageReference ValuesRisk AssessmentChemicalsDetrimentHealth risk assessmentNominal riskRadiationToxicological reference value

Identifiers

PMID34487227

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.