ReviewJournal of Alzheimer's disease : JAD2021
An Integrative Literature Review on the Nomenclature and Definition of Dementia at a Young Age.
Review in Journal of Alzheimer's disease : JAD, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Dementia in Rare Genetic Neurodevelopmental Disorders: A Systematic Literature Review.Neurology · 2024Pooled it
- Blood-based multimodal biomarker models for differentiating early-onset Alzheimer's disease from frontotemporal dementia: a longitudinal study of early-onset dementia and family members (LEAF) study.Journal of neurology · 2026Article
- Comparison of pre-diagnostic signs and symptoms of young-onset dementia and late-onset dementia in the general practice.Journal of Alzheimer's disease : JAD · 2026Article
- Plasma Biomarkers and Clinical Outcomes in Early-Onset Dementia.JAMA network open · 2026Article
- Assessing the risk of early-onset dementia within 5 years of cancer diagnosis Running Title: Early-onset dementia after cancer diagnosis.medRxiv : the preprint server for health sciences · 2026Article
- Neurodevelopmental Vulnerability in Alzheimer's Disease and Frontotemporal Dementia.European journal of neurology · 2025Article
- Blood biomarker profiles in young-onset neurocognitive disorders: A cohort study.The Australian and New Zealand journal of psychiatry · 2025Article
- Online peer support for Young Onset Dementia is a promising resource, but not a panacea: a commentary from the INTERDEM Young Onset Dementia taskforce.Frontiers in dementia · 2025Article
- Global burden of dementia in younger people: an analysis of data from the 2021 Global Burden of Disease Study.EClinicalMedicine · 2024Article
- 'Too young to sit at home': a qualitative study conducted among employees with young-onset dementia and their relatives.Aging & mental health · 2024Article
- Caring for people with dementia during the COVID-19 pandemic:a systematic review.Dementia & neuropsychologia · 2024Article
- "When she goes out, she feels better:" co-designing a Green Activity Program with Hispanic/Latino people living with memory challenges and care partners.Frontiers in aging neuroscience · 2024Article
- Diagnosis and Care Use for People with Young-Onset Dementia in Primary Care in the Netherlands.Journal of Alzheimer's disease : JAD · 2023Article
- Behind closed doors. A case study exploring the lived experiences of a family of a person with the behavioral variant of frontotemporal dementia.Dementia (London, England) · 2022Article
- A cross-sectional evaluation of the Dutch RHAPSODY program: online information and support for caregivers of persons with young-onset dementia.Internet interventions · 2022Article
- Strengthening the National Care System for Young Onset Dementia.International journal of public health · 2022Article
- Pre-Diagnostic Symptoms of Young-Onset Dementia in the General Practice up to Five Years Before Diagnosis.Journal of Alzheimer's disease : JAD · 2022Article
- Young-onset dementia in memory clinics in the Netherlands: Study design and description of PRECODE-GP.Alzheimer's & dementia (Amsterdam, Netherlands)Article
- Global, regional, and national burdens of early-onset Alzheimer's disease and other dementias in women, 1990 to 2021.Journal of Alzheimer's disease reportsArticle
- A Bayesian analysis of diagnostic timelines across Alzheimer's disease, frontotemporal dementia, and other neurodegenerative conditions.Alzheimer's & dementia (Amsterdam, Netherlands)Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThere has been growing interest in young people living with dementia. Future research requires consensus on the terminology and operational definition of this group.
objectiveThe purpose of this integrative review was to explore and include all operational definitions used to define dementia at a young age.
methodsOn August 14, 2020, the PubMed, Embase, Cinahl, and PsycInfo databases were searched for empirical and theoretical literature using Google. Various terms to describe and define 'dementia' and 'at a young age' were used to collect literature concerning terminology; age-related aspects, including cut-off ages and criteria; and etiologies of dementia at a young age.
resultsThe search yielded 6,891 empirical and 4,660 theoretical publications, resulting in the inclusion of 89 publications, including 36 publications containing an explicit discussion and 53 publications as confirmation. 'Young-onset dementia' was the most commonly used term of seven identified terms, in the last two decades. The age of 65 years at symptom onset was used most frequently when considering a total of six upper age limits and four criteria to define a cut-off age. Eight lower age limits and an option for subdivision based on age were included. We identified 251 different etiologies and 27 categories of etiologies.
conclusionDespite relative consensus on the term young-onset dementia and an age at symptom onset being used as a cut-off criterion, much is still unclear concerning possible etiologies of dementia at a young age. In the current study, controversies were detected for discussion in an international consensus study.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.