Evidence map›Paper›PMID 34486984›Full record

ReviewReproduction (Cambridge, England)2021

REPRODUCTIVE TOXICOLOGY: Pregnancy exposure to endocrine disrupting chemicals: implications for women's health.

Diana K Haggerty, Kristen Upson, Diana C Pacyga, J Ebba Franko, Joseph M Braun, Rita S Strakovsky

Open access · bronzeAbstract readReview
In one paragraph

Review in Reproduction (Cambridge, England), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
2.2field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 30 citations in OpenAlex.

  1. Associations of endocrine disrupting chemicals with anogenital distance across infancy.The Journal of clinical endocrinology and metabolism · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Diana K HaggertyDepartment of Food Science and Human Nutrition, Michigan State University, East Lansing, Michigan, USA.
Kristen UpsonDepartment of Epidemiology and Biostatistics, College of Human Medicine, Michigan State University, East Lansing, Michigan, USA.
Diana C PacygaDepartment of Food Science and Human Nutrition, Michigan State University, East Lansing, Michigan, USA.
J Ebba FrankoDepartment of Food Science and Human Nutrition, Michigan State University, East Lansing, Michigan, USA.
Joseph M BraunDepartment of Epidemiology, Brown University School of Public Health, Providence, Rhode Island, USA.
Rita S StrakovskyDepartment of Food Science and Human Nutrition, Michigan State University, East Lansing, Michigan, USA.
Michigan State University · USBrown University · US

Funding

Exposure to phthalate mixtures in pregnancy and long-term consequences for maternal metabolic and hormonal statusR01ES032227 · NIEHS · MICHIGAN STATE UNIVERSITY · PI STRAKOVSKY, RITA S. · 2020 to 2025
$2.1M
Endocrine Disruptors: Maternal Estrogen, Metabolism and Fetal Fatty Acid SupplyR00ES024795 · NIEHS · MICHIGAN STATE UNIVERSITY · PI STRAKOVSKY, RITA S. · 2017 to 2019
$729k
Endocrine Disruptors: Maternal Estrogen, Metabolism and Fetal Fatty Acid SupplyK99ES024795 · NIEHS · UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN · PI STRAKOVSKY, RITA S. · 2015 to 2016
$198k
NIEHS NIH HHS K99 ES024795NIEHS NIH HHS R00 ES024795NIEHS NIH HHS R01 ES032227
6 · The paper itself

Abstract

Women are ubiquitously exposed to non-persistent endocrine disrupting chemicals (EDCs) from food contact materials and personal care products. Understanding the impacts of exposure to these chemicals on pregnancy and long-term health outcomes in women is a critical area of research that has been largely overlooked. This brief review focuses on the epidemiologic literature exploring associations of non-persistent EDCs - including phthalates, parabens, bisphenols, and triclosan - with maternal pregnancy outcomes and long-term health outcomes in women. We focus on the challenges of this research, particularly assessing non-persistent EDC exposures, aspects of study design, and statistical approaches. We conclude by reviewing the best practices for non-persistent EDC research with regards to pregnancy and women's health. Though limited, we found some evidence indicating that exposure to non-persistent EDCs is associated with pregnancy health. However, findings from these studies have been inconsistent and require corroboration. Recent studies have also proposed that non-persistent EDC exposures in pregnancy may adversely affect postnatal maternal health. To date, only a few studies have been conducted and have only focused on postpartum weight. More research is needed in this area to inform efforts to promote optimal health across the lifespan of women.

Indexed as

Endocrine DisruptorsTriclosanFemaleHumansPregnancyPregnancy OutcomeWomen's HealthEndocrine DisruptorsTriclosan

Identifiers

PMID34486984
PMCPMC8511181
OpenAlexW3197649833

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.