Evidence map›Paper›PMID 34486781›Full record

ArticleRapid communications in mass spectrometry : RCM2023

Discovery proteomics of human placental tissue.

Allyson L Mellinger, Krista McCoy, Duy An T Minior, Taufika Islam Williams

Open access · bronzeAbstract read
In one paragraph

Article in Rapid communications in mass spectrometry : RCM, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.1field-weighted citation impact, top 56% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Allyson L MellingerDepartment of Chemistry, North Carolina State University, Raleigh, North Carolina, USA.ORCID https://orcid.org/0000-0002-0025-2393
Krista McCoyDepartment of Biology, East Carolina University, Greenville, North Carolina, USA.
Duy An T MiniorDivision of Neonatal-Perinatal Medicine, East Carolina University/The Brody School of Medicine, Greenville, North Carolina, USA.
Taufika Islam WilliamsDepartment of Chemistry, North Carolina State University, Raleigh, North Carolina, USA.ORCID https://orcid.org/0000-0002-5838-4647
East Carolina University · USNorth Carolina State University · US

Funding

Translational Research Support CoreP30ES025128 · NIEHS · NORTH CAROLINA STATE UNIVERSITY RALEIGH · PI Sue Fenton · 2015 to 2026
$18.3M
Nutraceutical reduction of endocrine disrupting chemical induced hypospadiasR15ES028436 · NIEHS · EAST CAROLINA UNIVERSITY · PI MCCOY, KRISTA · 2018 to 2018
$453k
NIEHS NIH HHS P30 ES025128NIEHS NIH HHS P30ES025128NIEHS NIH HHS R15 ES028436NIEHS NIH HHS R15ES028436
6 · The paper itself

Abstract

We describe a label-free proteomics protocol for the interrogation of the placental proteome. Step-by-step directions, including tissue cleanup and preparation, proteolytic digestion, nanoLC-MS/MS data collection and data analysis, are provided. The workflow has been applied toward exploring differential protein expression patterns in placentas from women who have been exposed to drugs during pregnancy relative to those who have not. We collected 20 tissue specimens, each representing a combination of spatially diverse sections across the placenta. These specimens were analyzed in the work described here, to survey information across the entire organ. This protocol can be scaled up or down as needed.

Indexed as

PlacentaTandem Mass SpectrometryFemaleHumansPregnancyProteolysisProteomeProteomicsProteome

Identifiers

PMID34486781
PMCPMC9218992
OpenAlexW3198220194

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.