Evidence map›Paper›PMID 34486392›Full record

ReviewPhysiological reviews2022

The role of globins in cardiovascular physiology.

T C Stevenson Keller, Christophe Lechauve, Alexander S Keller, Steven Brooks, Mitchell J Weiss, Linda Columbus, Hans Ackerman, Miriam M Cortese-Krott, Brant E Isakson

Open access · greenAbstract readReview
In one paragraph

Review in Physiological reviews, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
2.7field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 39 citations in OpenAlex.

  1. Sickle Trait Hemoglobin Does Not Influence Anopheles Biting Rates.The American journal of tropical medicine and hygiene · 2026
    Article
  2. Sickle-trait hemoglobin does not influencemedRxiv : the preprint server for health sciences · 2025
    Article
  3. Article
  4. Article
  5. Article
  6. Review
  7. Article
  8. Article
  9. Article
  10. Article
  11. Review
  12. Article
  13. Review
  14. Article
  15. Article
  16. Article
  17. Review
  18. Redox-Regulation of α-Globin in Vascular Physiology.Antioxidants (Basel, Switzerland) · 2022
    Article
  19. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 3 countries.

T C Stevenson KellerRobert M. Berne Cardiovascular Research Center, University of Virginia School of Medicine, Charlottesville, Virginia.
Christophe LechauveDepartment of Hematology, St. Jude Children's Research Hospital, Memphis, Tennessee.
Alexander S KellerRobert M. Berne Cardiovascular Research Center, University of Virginia School of Medicine, Charlottesville, Virginia.
Steven BrooksPhysiology Unit, Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, Rockville, Maryland.
Mitchell J WeissDepartment of Hematology, St. Jude Children's Research Hospital, Memphis, Tennessee.
Linda ColumbusDepartment of Chemistry, University of Virginia, Charlottesville, Virginia.
Hans AckermanPhysiology Unit, Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, Rockville, Maryland.
Miriam M Cortese-KrottMyocardial Infarction Research Laboratory, Department of Cardiology, Pulmonology, and Angiology, Medical Faculty, Heinrich Heine University of Düsseldorf, Düsseldorf, Germany.
Brant E IsaksonRobert M. Berne Cardiovascular Research Center, University of Virginia School of Medicine, Charlottesville, Virginia.ORCID 0000-0002-7692-6294
University of Virginia · USNational Institute of Allergy and Infectious Diseases · USSt. Jude Children's Research Hospital · USKarolinska Institutet · SE

Funding

Role of Pannexins in Vascular Smooth Muscle CellsP01HL120840 · NHLBI · UNIVERSITY OF VIRGINIA · PI BAYLISS, DOUGLAS A., RAVICHANDRAN, KODI S · 2014 to 2023
$24.0M
Nitric Oxide and Endothelial Function in Patients with MalariaZIAAI001150 · NIAID · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · PI ACKERMAN, HANS · 2011 to 2025
$19.4M
Biophysical understanding of pathogen-host membrane protein interactions for drug discovery and deliveryR35GM131829 · NIGMS · UNIVERSITY OF VIRGINIA · PI Linda M Columbus · 2019 to 2026
$3.2M
NHLBI NIH HHS P01 HL120840NIGMS NIH HHS R35 GM131829
6 · The paper itself

Abstract

Globin proteins exist in every cell type of the vasculature, from erythrocytes to endothelial cells, vascular smooth muscle cells, and peripheral nerve cells. Many globin subtypes are also expressed in muscle tissues (including cardiac and skeletal muscle), in other organ-specific cell types, and in cells of the central nervous system (CNS). The ability of each of these globins to interact with molecular oxygen (O

Indexed as

Cardiovascular Physiological PhenomenaAnimalsCytoglobinEndothelial CellsGlobinsHumansMyoglobinNeuroglobinCytoglobinGlobinsMyoglobinNeuroglobinglobinnitric oxidevasculature

Identifiers

PMID34486392
PMCPMC8799389
OpenAlexW3198060971

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.