ArticleEpilepsia2021
Features of intracranial interictal epileptiform discharges associated with memory encoding.
Article in Epilepsia, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
7 citing papers in PubMed.
- Multisensory flicker modulates widespread brain networks and reduces interictal epileptiform discharges.Nature communications · 2024Trial
- Laminar organization of cellular microcircuits modulating human interictal epileptiform discharges.Nature neuroscience · 2026Article
- Behavioral Timing of Interictal Spikes, But Not Rate, Correlates with Impaired Working Memory Performance.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Rest-activity rhythm phenotypes in adults with epilepsy and intellectual disability.Epilepsia open · 2025Article
- Interictal network dysfunction and cognitive impairment in epilepsy.Nature reviews. Neuroscience · 2025Review
- Interictal spikes during spatial working memory carry helpful or distracting representations of space and have opposing impacts on performance.bioRxiv : the preprint server for biology · 2024Article
- Hippocampal Theta and Episodic Memory.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023Article
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Authors and funding
12 authors.
Funding
Abstract
objectiveInterictal epileptiform discharges (IEDs) were shown to be associated with cognitive impairment in persons with epilepsy. Previous studies indicated that IED rate, location, timing, and spatial relation to the seizure onset zone could predict an IED's impact on memory encoding and retrieval if they occurred in lateral temporal, mesial temporal, or parietal regions. In this study, we explore the influence that other IED properties (e.g., amplitude, duration, white matter classification) have on memory performance. We were specifically interested in investigating the influence that lateral temporal IEDs have on memory encoding.
methodsTwo hundred sixty-one subjects with medication-refractory epilepsy undergoing intracranial electroencephalographic monitoring performed multiple sessions of a delayed free-recall task (n = 671). Generalized linear mixed models were utilized to examine the relationship between IED properties and memory performance.
resultsWe found that increased IED rate, IEDs propagating in white matter, and IEDs localized to the left middle temporal region were associated with poorer memory performance. For lateral temporal IEDs, we observed a significant interaction between IED white matter categorization and amplitude, where IEDs with an increased amplitude and white matter propagation were associated with reduced memory performance. Additionally, changes in alpha power after an IED showed a significant positive correlation with memory performance. SIGNIFICANCE: Our results suggest that IED properties may be useful for predicting the impact an IED has on memory encoding. We provide an essential step toward understanding pathological versus potentially beneficial interictal epileptiform activity.
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