Evidence map›Paper›PMID 34485965›Full record

ArticleAmerican journal of preventive cardiology2021

Cost-effectiveness of cascade genetic testing for familial hypercholesterolemia in the United States: A simulation analysis.

Candace L Jackson, Todd Huschka, Bijan Borah, Katherine Agre, Magdi Zordok, Medhat Farwati, James Moriarty, Iftikhar J Kullo

Open access · goldAbstract read
In one paragraph

Article in American journal of preventive cardiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed, 1 pooled it
4.6field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 1 synthesis or guideline pooled it, 30 citations in OpenAlex.

  1. Pooled it
  2. Article
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  5. Article
  6. Review
  7. Article
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  11. Article
  12. A pragmatic clinical trial of cascade testing for familial hypercholesterolemia.Genetics in medicine : official journal of the American College of Medical Genetics · 2022
    Article
  13. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Candace L JacksonDepartment of Medicine, Mayo Clinic, Rochester, MN, United States.
Todd HuschkaMayo Clinic Robert D. and Patricia E. Kern Center for the Science of Health Care Delivery, Mayo Clinic, Rochester, MN, United States.
Bijan BorahMayo Clinic Robert D. and Patricia E. Kern Center for the Science of Health Care Delivery, Mayo Clinic, Rochester, MN, United States.
Katherine AgreClinical Genomics, Mayo Clinic, Rochester, MN, United States.
Magdi ZordokDepartment of Cardiovascular Medicine and the Gonda Vascular Center, Mayo Clinic, Rochester, MN, United States.
Medhat FarwatiDepartment of Cardiovascular Medicine and the Gonda Vascular Center, Mayo Clinic, Rochester, MN, United States.
James MoriartyMayo Clinic Robert D. and Patricia E. Kern Center for the Science of Health Care Delivery, Mayo Clinic, Rochester, MN, United States.
Iftikhar J KulloDepartment of Cardiovascular Medicine and the Gonda Vascular Center, Mayo Clinic, Rochester, MN, United States.
Mayo Clinic · USMayo Clinic in Arizona · USMayo Clinic in Florida · US

Funding

Genomic Basis of Susceptibility to COVID-19 Infection and its ComplicationsU01HG006379 · NHGRI · MAYO CLINIC ROCHESTER · PI Richard R. Sharp · 2011 to 2026
$16.5M
Patient-Oriented Research in Genomic Discovery and ImplementationK24HL137010 · NHLBI · MAYO CLINIC ROCHESTER · PI KULLO, IFTIKHAR J · 2017 to 2021
$590k
NHGRI NIH HHS U01 HG006379NHLBI NIH HHS K24 HL137010
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Cascade testingFamilial hypercholesterolemiaGenetic testingPrevention

Identifiers

PMID34485965
PMCPMC8403726
OpenAlexW3195977032

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.