Evidence map›Paper›PMID 34485913›Full record

ArticleFunction (Oxford, England)2021

The Molecular Basis of Glucose Galactose Malabsorption in a Large Swedish Pedigree.

M Pilar Lostao, Donald D Loo, Olle Hernell, Gunnar Meeuwisse, Martin G Martin, Ernest M Wright

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Function (Oxford, England), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.5field-weighted citation impact, top 38% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 8 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
  4. Genes · 2023
    Article
  5. Review
  6. Human Glucose Transporters in Renal Glucose Homeostasis.International journal of molecular sciences · 2021
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

M Pilar LostaoDepartments of Physiology and Pediatrics, The David Geffen School of Medicine at UCLA, Los Angeles, CA 90095-1751, USA.
Donald D LooDepartment of Physiology, The Geffen School of Medicine, UCLA, USA.
Olle HernellDepartments of Physiology and Pediatrics, The David Geffen School of Medicine at UCLA, Los Angeles, CA 90095-1751, USA.
Gunnar MeeuwisseDepartments of Physiology and Pediatrics, The David Geffen School of Medicine at UCLA, Los Angeles, CA 90095-1751, USA.
Martin G MartinDepartments of Physiology and Pediatrics, The David Geffen School of Medicine at UCLA, Los Angeles, CA 90095-1751, USA.
Ernest M WrightDepartments of Physiology and Pediatrics, The David Geffen School of Medicine at UCLA, Los Angeles, CA 90095-1751, USA.
University of California, Los Angeles · US

Funding

COngenital Diarrhea and Enteropathy (PediCODE) Consortium and BioRepositoryRC2DK118640 · NIDDK · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI James Richard Goldenring, Izumi Kaji · 2019 to 2026
$14.8M
MOLECULAR MECHANISMS OF INTESTINAL TRANSPORTR01DK019567 · NIDDK · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI WRIGHT, ERNEST M · 1986 to 2013
$4.3M
Intestinal Stem Cell Culture and Entero-Endocrine Lineage DevelopmentU01DK085535 · NIDDK · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI DUNN, JAMES C, MARTIN, MARTIN G · 2009 to 2018
$3.7M
Limited Competition for the Continuation of the Intestinal Stem Cell Consortium Coordinating CenterU24DK085532 · NIDDK · BECKMAN RESEARCH INSTITUTE/CITY OF HOPE · PI NILAND, JOYCE CAROL · 2019 to 2023
$2.3M
Neurogenin3 and Intestinal FailureR01DK083762 · NIDDK · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI MARTIN, MARTIN G · 2009 to 2012
$1.6M
Cell Fate Determination of the Intestine and Chronic Diarrhea in ChildrenR21DK075009 · NIDDK · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI MARTIN, MARTIN G · 2006 to 2007
$305k
NIDDK NIH HHS R01 DK019567NIDDK NIH HHS R01 DK083762NIDDK NIH HHS R21 DK075009NIDDK NIH HHS RC2 DK118640NIDDK NIH HHS U01 DK085535NIDDK NIH HHS U24 DK085532
6 · The paper itself

Abstract

Glucose-galactose malabsorption (GGM) is due to mutations in the gene coding for the intestinal sodium glucose cotransporter SGLT1 (SLC5A1). Here we identify the rare variant Gln457Arg (Q457R) in a large pedigree of patients in the Västerbotten County in Northern Sweden with the clinical phenotype of GGM. The functional effect of the Q457R mutation was determined in protein expressed in

Indexed as

GlucoseA Kinase Anchor ProteinsCarbohydrate Metabolism, Inborn ErrorsCell MembraneHumansMalabsorption SyndromesPedigreeSwedenAKAP5 protein, humanA Kinase Anchor ProteinsGlucoseGGM mutation SGLT1 structureglucose-galactose malabsorption Swedish GGM pedigreeSGLT1sodium glucose cotransporter

Identifiers

PMID34485913
PMCPMC8410129
OpenAlexW3194787006

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.