Evidence map›Paper›PMID 34485784›Full record

ArticleIEEE transactions on radiation and plasma medical sciences2021

Photon Counting CT: Clinical Applications and Future Developments.

Scott S Hsieh, Shuai Leng, Kishore Rajendran, Shengzhen Tao, Cynthia H McCollough

Abstract read
In one paragraph

Article in IEEE transactions on radiation and plasma medical sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 71 papers.

0numbers the graph read from it
0cells of the map it votes in
71citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

71 citing papers in PubMed.

  1. Article
  2. Review
  3. Review
  4. K-Edge imaging using a clinical dual-source photon-counting CT system.Journal of applied clinical medical physics · 2026
    Article
  5. Review
  6. Article
  7. Article
  8. Article
  9. Article
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  11. Article
  12. Article
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  15. Article
  16. Review
  17. Article
  18. Article
  19. Clinical applications of portable CT scanners.The British journal of radiology · 2025
    Review
  20. Article

11 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Scott S HsiehDepartment of Radiology at the Mayo Clinic, Rochester MN 55905 USA.
Shuai LengDepartment of Radiology at the Mayo Clinic, Rochester MN 55905 USA.
Kishore RajendranDepartment of Radiology at the Mayo Clinic, Rochester MN 55905 USA.
Shengzhen TaoDepartment of Radiology at the Mayo Clinic, Rochester MN 55905 USA.
Cynthia H McColloughDepartment of Radiology at the Mayo Clinic, Rochester MN 55905 USA.

Funding

Photon-Counting Spectral CT to Reduce Dose and Detect Early Vascular DiseaseR01EB016966 · NIBIB · MAYO CLINIC ROCHESTER · PI MCCOLLOUGH, CYNTHIA H · 2013 to 2017
$5.1M
EXTRAMURAL RES FACIL IMPROVEMENT PROG: POLYCYSTIC KIDNEY DISEASE, RENAL STUDIES,C06RR018898 · NCRR · MAYO CLINIC · PI BURNETT, JOHN C · 2004 to 2004
$2.3M
NCRR NIH HHS C06 RR018898NIBIB NIH HHS R01 EB016966
6 · The paper itself

Abstract

The use of a photon counting detector in CT (PCD CT) is currently the subject of intense investigation and development. In this review article, we will describe potential clinical applications of this technology with a particular focus on the experience of our own institution with a prototype PCD CT scanner. PCDs have three primary advantages over conventional, energy integrating detectors (EIDs): they provide spectral information without need for a dedicated dual energy protocol; they are immune to electronic noise; and they can be made very high resolution without significant compromises to quantum efficiency. These advantages translate into several clinical applications. Metal artifacts, beam hardening artifacts, and noise streaks from photon starvation can be better mitigated using PCD CT. Certain incidental findings can be better characterized using the spectral information from PCD CT. High-contrast, high-resolution structures such as the temporal bone can be better visualized using PCD CT and at greatly reduced dose. We also discuss new possibilities on the horizon, including new contrast agents, and how anticipated improvements in PCD CT will translate to performance in these applications.

Indexed as

clinical applicationsphoton counting X-ray detectorsspectral CT

Identifiers

PMID34485784
PMCPMC8409241

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.