Evidence map›Paper›PMID 34485766›Full record

ArticleCell surface (Amsterdam, Netherlands)2021

Elimination of PknL and MSMEG_4242 in

Estalina Báez-Ramírez, Luis Querales, Carlos Andres Aranaga, Gustavo López, Elba Guerrero, Laurent Kremer, Séverine Carrère-Kremer, Albertus Viljoen, Mamadou Daffé, Françoise Laval and 7 more

Open access · goldAbstract read
In one paragraph

Article in Cell surface (Amsterdam, Netherlands), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.2field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 12 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors at 7 institutions in 4 countries.

Estalina Báez-RamírezLaboratorio de Genétic Molecular, CMBC, Instituto Venezolano de Investigaciones Científicas (IVIC), Caracas, Venezuela.
Luis QueralesLaboratorio de Genétic Molecular, CMBC, Instituto Venezolano de Investigaciones Científicas (IVIC), Caracas, Venezuela.
Carlos Andres AranagaLaboratorio de Genétic Molecular, CMBC, Instituto Venezolano de Investigaciones Científicas (IVIC), Caracas, Venezuela.
Gustavo LópezLaboratorio de Genétic Molecular, CMBC, Instituto Venezolano de Investigaciones Científicas (IVIC), Caracas, Venezuela.
Elba GuerreroLaboratorio de Genétic Molecular, CMBC, Instituto Venezolano de Investigaciones Científicas (IVIC), Caracas, Venezuela.
Laurent KremerInstitut de Recherche en Infectiologie de Montpellier, Centre National de la Recherche Scientifique UMR 9004, Université de Montpellier, Montpellier, France.
Séverine Carrère-KremerInstitut de Recherche en Infectiologie de Montpellier, Centre National de la Recherche Scientifique UMR 9004, Université de Montpellier, Montpellier, France.
Albertus ViljoenInstitut de Recherche en Infectiologie de Montpellier, Centre National de la Recherche Scientifique UMR 9004, Université de Montpellier, Montpellier, France.
Mamadou DafféInstitut de Pharmacologie et de Biologie Structurale, Université de Toulouse, France.
Françoise LavalInstitut de Pharmacologie et de Biologie Structurale, Université de Toulouse, France.
Stewart T ColeEPFL, Lauzanne, Switzerland.
Andrej BenjakEPFL, Lauzanne, Switzerland.
Pedro AlzariUnit of Structural Microbiology, Institut Pasteur, Paris, France.
Gwenaëlle André-LerouxUnit of Structural Microbiology, Institut Pasteur, Paris, France.
William R JacobsDepartment of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, NY, USA.
Catherine VilchezeDepartment of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, NY, USA.
Howard E TakiffLaboratorio de Genétic Molecular, CMBC, Instituto Venezolano de Investigaciones Científicas (IVIC), Caracas, Venezuela.
Instituto Venezolano de Investigaciones Científicas · VEAlbert Einstein College of Medicine · USÉcole Polytechnique Fédérale de Lausanne · CHInstitut de Pharmacologie et de Biologie Structurale · FRInstitut Pasteur · FRUniversité de Montpellier · FRInstitut de Recherche en Infectiologie de Montpellier · FR

Funding

Molecular Genetic Analysis of Mycobacterium TuberculosisR37AI026170 · NIAID · ALBERT EINSTEIN COL OF MED YESHIVA UNIV · PI WILLIAM Robert JACOBS · 2004 to 2026
$7.7M
MOLECULAR GENETIC ANALYSIS OF MYCOBACTERIUM TUBERCULOSISR01AI026170 · NIAID · YESHIVA UNIVERSITY · PI JACOBS, WILLIAM ROBERT · 1989 to 2022
$7.1M
NIAID NIH HHS R01 AI026170NIAID NIH HHS R37 AI026170
6 · The paper itself

Abstract

Four serine/threonine kinases are present in all mycobacteria: PknA, PknB, PknG and PknL. PknA and PknB are essential for growth and replication, PknG regulates metabolism, but little is known about PknL. Inactivation of

Indexed as

BiofilmsKinaseLsr2Mycobacterial envelopePknLTuberculosis

Identifiers

PMID34485766
PMCPMC8408660
OpenAlexW3194624962

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.