Evidence map›Paper›PMID 34485682›Full record

ArticleApplied materials today2021

Fibrous heart valve leaflet substrate with native-mimicked morphology.

Soumen Jana, Federico Franchi, Amir Lerman

Open access · greenAbstract read
In one paragraph

Article in Applied materials today, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.0field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 16 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Soumen JanaDepartment of Bioengineering, University of Missouri, Columbia, MO 65211, USA.
Federico FranchiDepartment of Cardiovascular Medicine, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA.
Amir LermanDepartment of Cardiovascular Medicine, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA.
Mayo Clinic · US

Funding

Nanotechnology in tissue engineering for autologous cardiac valve developmentR00HL134823 · NHLBI · UNIVERSITY OF MISSOURI-COLUMBIA · PI JANA, SOUMEN · 2019 to 2021
$745k
Nanotechnology in tissue engineering for autologous cardiac valve developmentK99HL134823 · NHLBI · MAYO CLINIC ROCHESTER · PI JANA, SOUMEN · 2017 to 2018
$256k
NHLBI NIH HHS K99 HL134823NHLBI NIH HHS R00 HL134823
6 · The paper itself

Abstract

Tissue-engineered heart valves are a promising alternative solution to prosthetic valves. However, long-term functionalities of tissue-engineered heart valves depend on the ability to mimic the trilayered, oriented structure of native heart valve leaflets. In this study, using electrospinning, we developed trilayered microfibrous leaflet substrates with morphological characteristics similar to native leaflets. The substrates were implanted subcutaneously in rats to study the effect of their trilayered oriented structure on

Indexed as

electrospinningfiberHeart valve leafletin vivo tissue engineeringtrilayered

Identifiers

PMID34485682
PMCPMC8415466
OpenAlexW3184743491

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.