ArticleNeurobiology of stress2021
A prospective examination of sex differences in posttraumatic autonomic functioning.
Article in Neurobiology of stress, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06429293 (Impact of Cognitive Behavioral Therapy on Neural, Inflammatory, & Autonomic Markers in a Sample With PTSD and Cardiovascular Risk), which is not on this map. Cited by 16 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Impact of Cognitive Behavioral Therapy on Neural, Inflammatory, & Autonomic Markers in a Sample With PTSD and Cardiovascular Risk: Protocol for a Pilot Randomized Controlled Trial
Who cites it
16 citing papers in PubMed, 1 synthesis or guideline pooled it, 22 citations in OpenAlex.
- Understanding the comorbidity between posttraumatic stress severity and coronary artery disease using genome-wide information and electronic health records.Molecular psychiatry · 2022Pooled it
- Peritraumatic C-reactive protein levels predict pain outcomes following traumatic stress exposure in a sex-dependent manner.The journal of pain · 2026Article
- Post-traumatic stress disorder and cardiometabolic dysfunction: Molecular mechanisms and therapeutic targets.iScience · 2026Review
- The impact of trauma and how to intervene: a narrative review of psychotraumatology over the past 15 years.European journal of psychotraumatology · 2025Article
- Associations between PACAP levels and psychophysiological indicators of fear and arousal in adults with posttraumatic stress symptoms.Journal of mood and anxiety disorders · 2025Article
- Longitudinal Associations Between Peritraumatic Oestradiol and Fear Responding in Women and Men.Stress and health : journal of the International Society for the Investigation of Stress · 2025Article
- Posttraumatic stress disorder increases thrombosis risk: Evidence from a biobank data set.American journal of hematology · 2024Article
- Probing the neurocardiac circuit in trauma and posttraumatic stress.Journal of psychiatric research · 2024Article
- Resting heart rate associations with violence exposure and posttraumatic stress symptoms: sex differences in children.Biology of sex differences · 2024Article
- Mismatch between subjective and objective dysautonomia.Scientific reports · 2024Article
- Impact of cognitive behavioural therapy on neural, inflammatory, & autonomic markers in a sample with PTSD and cardiovascular risk: protocol for a pilot randomised controlled trial.European journal of psychotraumatology · 2024Article
- Sex-Based Contributors to and Consequences of Post-traumatic Stress Disorder.Current psychiatry reports · 2023Review
- Psychophysiological reactions during the trauma-film paradigm and their predictive value for intrusions.European journal of psychotraumatology · 2023Article
- Biological Psychiatry in Displaced Populations: What We Know, and What We Need to Begin to Learn.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2022Review
- Sex-differential PTSD symptom trajectories across one year following suspected serious injury.European journal of psychotraumatology · 2022Article
- AI-Based Prediction and Prevention of Psychological and Behavioral Changes in Ex-COVID-19 Patients.Frontiers in psychology · 2021Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
58 authors at 20 institutions in 2 countries.
Funding
Abstract
backgroundCross-sectional studies have found that individuals with posttraumatic stress disorder (PTSD) exhibit deficits in autonomic functioning. While PTSD rates are twice as high in women compared to men, sex differences in autonomic functioning are relatively unknown among trauma-exposed populations. The current study used a prospective design to examine sex differences in posttraumatic autonomic functioning.
methods192 participants were recruited from emergency departments following trauma exposure (
results2-week systolic BP was significantly higher in men, while 2-week HR was significantly higher in women, and a sex by PTSD interaction suggested that women who developed PTSD demonstrated the highest HR levels. Two-week HF-HRV was significantly lower in women, and a sex by PTSD interaction suggested that women with PTSD demonstrated the lowest HF-HRV levels. Skin conductance response in the emergency department was associated with 2-week HR and HF-HRV only among women who developed PTSD.
conclusionsOur results indicate that there are notable sex differences in autonomic functioning among trauma-exposed individuals. Differences in sympathetic biomarkers (BP and HR) may have implications for cardiovascular disease risk given that sympathetic arousal is a mechanism implicated in this risk among PTSD populations. Future research examining differential pathways between PTSD and cardiovascular risk among men versus women is warranted.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.