Evidence map›Paper›PMID 34485630›Full record

ArticleCurrent opinion in behavioral sciences2021

Improving autobiographical memory in Alzheimer's disease by transcranial alternating current stimulation.

Lucie Bréchet, Christoph M Michel, Daniel L Schacter, Alvaro Pascual-Leone

Registry-linked trialAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Current opinion in behavioral sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05708001 (Improvement of Memory in Mild Cognitive Impairment), which is not on this map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05708001 narecruitingnot on this mapstarted 2023, after this paper: background citation

Improvement of Memory in Mild Cognitive Impairment (MCI) Using Transcranial Alternating Current Stimulation (tACS) Guided by EEG and MRI: a Randomized, Sham-controlled, Parallel-arm, Double-blind Study

TypeinterventionalSponsorLucie BréchetRan2023 to 2027Enrolled40ConditionsMild Cognitive ImpairmentArmstranscranial alternating current stimulation (tACS), high-density electroencephalography (hdEEG), Montreal Cognitive Assessment (MoCA)
3 · Its place in the literature

Who cites it

15 citing papers in PubMed.

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  11. Why art? The role of arts in arts and health.Frontiers in psychology · 2023
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Lucie BréchetHinda and Arthur Marcus Institute for Aging Research and Deanna and Sidney Wolk Center for Memory Health, Hebrew SeniorLife, Boston, Massachusetts, USA.
Christoph M MichelFunctional Brain Mapping Laboratory, Fundamental Neuroscience Dept., University Geneva, Switzerland.
Daniel L SchacterDepartment of Psychology, Harvard University, Cambridge, MA.
Alvaro Pascual-LeoneHinda and Arthur Marcus Institute for Aging Research and Deanna and Sidney Wolk Center for Memory Health, Hebrew SeniorLife, Boston, Massachusetts, USA.

Funding

The Role of Inflammation in the Pathophysiology of Delirium and its Associated Long-Term Cognitive DeclineP01AG031720 · NIA · HEBREW REHABILITATION CENTER FOR AGED · PI SHAFI, MOUHSIN · 2010 to 2022
$26.7M
Episodic Retrieval and Problem Solving in AgingR01AG008441 · NIA · UNIVERSITY OF ARIZONA · PI SCHACTER, DANIEL L · 1989 to 2022
$3.1M
TERMINATE CA2+ RELEASE BY LOCAL INACTIVATION OF RYANODINE RECEPTORS(RYR)IN HEARTZ01AG000841 · NIA · AGING · PI CHENG, HEPING · 1996 to 2004
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Intramural NIH HHS Z01 AG000841NIA NIH HHS P01 AG031720NIA NIH HHS R01 AG008441
6 · The paper itself

Abstract

We review the latest evidence from animal models, studies in humans using electrophysiology, experimental memory paradigms, and non-invasive brain stimulation (NIBS), in the form of transcranial alternating current stimulation (tACS), suggesting that the altered activity in networks that contribute to the autobiographical memory (ABM) deficits may be modifiable. ABM involves a specific brain network of interacting regions that store and retrieve life experiences. Deficits in ABM are early symptoms in patients with Alzheimer's disease (AD), and serve as relevant predictors of disease progression. The possibility to modify the neural substrates of ABM opens exciting avenues for the development of therapeutic approaches. Beyond a summary of the causal role of brain oscillations in ABM, we propose a new approach of modulating brain oscillations using personalized tACS with the possibility of reducing ABM deficits. We suggest that human experimental studies using cognitive tasks, EEG, and tACS can have future translational clinical implications.

Indexed as

Alzheimer’s disease (AD)autobiographical memoryguided high-density electroencephalography (hdEEG)personalized montagestranscranial alternating current stimulation (tACS)

Identifiers

PMID34485630
PMCPMC8415489

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.