Evidence map›Paper›PMID 34485406›Full record

ReviewFrontiers in cardiovascular medicine2021

The Central Role of Left Atrium in Heart Failure.

Myriam Carpenito, Diego Fanti, Simona Mega, Giovanni Benfari, Maria Caterina Bono, Andrea Rossi, Flavio Luciano Ribichini, Francesco Grigioni

Abstract readReview
In one paragraph

Review in Frontiers in cardiovascular medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.

0numbers the graph read from it
0cells of the map it votes in
34citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

34 citing papers in PubMed.

  1. Article
  2. Article
  3. Observational
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Three-dimensional left atrial strain is associated with heart failure and cardiovascular death in the general population.Clinical research in cardiology : official journal of the German Cardiac Society · 2025
    Article
  13. Article
  14. Review
  15. Article
  16. Left Atrial Strain-Current Review of Clinical Applications.Diagnostics (Basel, Switzerland) · 2025
    Review
  17. Article
  18. Gut microbiota and atrial cardiomyopathy.Frontiers in cardiovascular medicine · 2025
    Review
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Myriam CarpenitoUnit of Cardiac Sciences, Department of Medicine, Campus Bio-Medico University of Rome, Rome, Italy.
Diego FantiSection of Cardiology, Department of Medicine, University of Verona, Verona, Italy.
Simona MegaUnit of Cardiac Sciences, Department of Medicine, Campus Bio-Medico University of Rome, Rome, Italy.
Giovanni BenfariSection of Cardiology, Department of Medicine, University of Verona, Verona, Italy.
Maria Caterina BonoUnit of Cardiac Sciences, Department of Medicine, Campus Bio-Medico University of Rome, Rome, Italy.
Andrea RossiSection of Cardiology, Department of Medicine, University of Verona, Verona, Italy.
Flavio Luciano RibichiniSection of Cardiology, Department of Medicine, University of Verona, Verona, Italy.
Francesco GrigioniUnit of Cardiac Sciences, Department of Medicine, Campus Bio-Medico University of Rome, Rome, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In past cardiovascular medicine, the attention to the left ventricle-identified as the only indicator and determinant of healthy or unhealthy cardiac conditions- has systematically hidden the role of the left atrium (LA). The recent advances in cardiovascular imaging have provided a better understanding of LA anatomy, physiology, and pathology, making us realize that this functional structure is far from being an innocent spectator. We now know that the LA's mechanical and neuro-hormonal properties play a relevant part in several cardiovascular diseases, including atrial fibrillation, ischemic heart disease, valvular heart disease, and heart failure. The present review aims to describe the role of LA in the specific setting of heart failure. We provide currently available information on LA structure and function and summarize its role as a determinant of symptoms, prognosis, and potential therapeutic target in heart failure patients.

Indexed as

cardiovascular diseaseheart failureleft atrial functionleft atrial strainleft atriumspeckle-tracking echocardiography

Identifiers

PMID34485406
PMCPMC8414134

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.