Evidence map›Paper›PMID 34485393›Full record

ArticleFrontiers in cardiovascular medicine2021

Long Non-coding RNA N1LR Protects Against Myocardial Ischemic/Reperfusion Injury Through Regulating the TGF-β Signaling Pathway.

Lin Du, Jie Chen, Yong Wu, Guangwei Xia, Mingxing Chen, Pei Zhao, Yao Wang, Deshan Yao, Fan Liu, Lina Zhang and 3 more

Open access · goldAbstract read
In one paragraph

Article in Frontiers in cardiovascular medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
0.7field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 10 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Article
  6. The Role of ncRNAs in Cardiac Infarction and Regeneration.Journal of cardiovascular development and disease · 2023
    Review
  7. Article
  8. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 4 institutions in 1 country.

Lin DuDepartment of Cardiology, The First Affiliated Hospital of Nanjing Medical University, Nanjing Medical University, Nanjing, China.
Jie ChenDepartment of Gastroenterology, Northern Jiangsu Province People's Hospital, Yangzhou University, Yangzhou, China.
Yong WuDepartment of Cardiology, Affiliated Hospital of Yangzhou University, Yangzhou University, Yangzhou, China.
Guangwei XiaDepartment of Cardiology, Affiliated Hospital of Yangzhou University, Yangzhou University, Yangzhou, China.
Mingxing ChenDepartment of Cardiology, Affiliated Hospital of Yangzhou University, Yangzhou University, Yangzhou, China.
Pei ZhaoDepartment of Cardiology, Affiliated Hospital of Yangzhou University, Yangzhou University, Yangzhou, China.
Yao WangDepartment of Cardiology, Affiliated Hospital of Yangzhou University, Yangzhou University, Yangzhou, China.
Deshan YaoDepartment of Cardiology, Affiliated Hospital of Yangzhou University, Yangzhou University, Yangzhou, China.
Fan LiuDepartment of Cardiology, Affiliated Hospital of Yangzhou University, Yangzhou University, Yangzhou, China.
Lina ZhangDepartment of Cardiology, Affiliated Hospital of Yangzhou University, Yangzhou University, Yangzhou, China.
Xue WangDepartment of Cardiology, Affiliated Hospital of Yangzhou University, Yangzhou University, Yangzhou, China.
Yi YangDepartment of Cardiology, Affiliated Hospital of Yangzhou University, Yangzhou University, Yangzhou, China.
Liansheng WangDepartment of Cardiology, The First Affiliated Hospital of Nanjing Medical University, Nanjing Medical University, Nanjing, China.
Yangzhou University · CNJiangsu Province Hospital · CNNanjing Medical University · CNNorthern Jiangsu People's Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Long non-coding RNAs (lncRNAs) have been shown to play critical roles in various cell biological processes. However, the mechanism of lncRNAs in acute myocardial infarction (AMI) is not fully understood. Previous studies showed that lncRNA N1LR was down-regulated in ischemic cerebral stroke and its up-regulation was protective. The current study was designed to assess the protective effect of N1LR and further to explore potential mechanisms of N1LR in ischemic/reperfusion (I/R) injury after AMI. Male C57BL/6J mice and H9c2 cardiomyocytes were selected to construct

Indexed as

acute myocardial infarctioncardiomyocytesischemic reperfusion injuryLncRNA N1LRTGF-β pathway

Identifiers

PMID34485393
PMCPMC8414635
OpenAlexW3193698070

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.