Evidence map›Paper›PMID 34485327›Full record

ArticleFrontiers in medicine2021

Case Report: SARS-CoV-2 Mother-to-Child Transmission and Fetal Death Associated With Severe Placental Thromboembolism.

Penélope Saldanha Marinho, Antonio José Ledo Alves da Cunha, Leila Chimelli, Elyzabeth Avvad-Portari, Felipe da Matta Andreiuolo, Patrícia Soares de Oliveira-Szejnfeld, Mayara Abud Mendes, Ismael Carlos Gomes, Letícia Rocha Q Souza, Marilia Zaluar Guimarães and 6 more

Open access · goldAbstract readCase Reports
In one paragraph

Article in Frontiers in medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed, 1 pooled it
6.6field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 1 synthesis or guideline pooled it, 40 citations in OpenAlex.

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  13. Laminar Necrosis and Hypoxic Damage of the Placenta: A Case-Control Study.International journal of environmental research and public health · 2022
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 5 institutions in 1 country.

Penélope Saldanha MarinhoMaternity School, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil.
Antonio José Ledo Alves da CunhaMaternity School, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil.
Leila ChimelliLaboratory of Neuropathology, Rio de Janeiro State Brain Institute, Rio de Janeiro, Brazil.
Elyzabeth Avvad-PortariDepartment of Pathological Anatomy, Fernandes Figueira Institute, Fiocruz, Rio de Janeiro, Brazil.
Felipe da Matta AndreiuoloLaboratory of Neuropathology, Rio de Janeiro State Brain Institute, Rio de Janeiro, Brazil.
Patrícia Soares de Oliveira-SzejnfeldDiagnostic Imaging Department, Escola Paulista de Medicina, School of Medicine, Universidade Federal de São Paulo, São Paulo, Brazil.
Mayara Abud MendesStem Cell Laboratory, D'Or Institute for Research and Education, Rio de Janeiro, Brazil.
Ismael Carlos GomesGenetics Department, Institute of Biology, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil.
Letícia Rocha Q SouzaStem Cell Laboratory, D'Or Institute for Research and Education, Rio de Janeiro, Brazil.
Marilia Zaluar GuimarãesStem Cell Laboratory, D'Or Institute for Research and Education, Rio de Janeiro, Brazil.
Suzan Menasce GoldmanDiagnostic Imaging Department, Escola Paulista de Medicina, School of Medicine, Universidade Federal de São Paulo, São Paulo, Brazil.
Mariana Barros Genuíno de OliveiraDepartment of Pediatrics, D'Or Institute for Research and Education, Rio de Janeiro, Brazil.
Stevens RehenDiagnostic Imaging Department, D'Or Institute for Research and Education, Rio de Janeiro, Brazil.
Joffre AmimMaternity School, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil.
Fernanda Tovar-MollDiagnostic Imaging Department, Escola Paulista de Medicina, School of Medicine, Universidade Federal de São Paulo, São Paulo, Brazil.
Arnaldo Prata-BarbosaMaternity School, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil.
D’Or Institute for Research and Education · BRUniversidade Federal do Rio de Janeiro · BRUniversidade Federal de São Paulo · BRBrazilian Institute of Neuropsychology and Behaviour · BRUniversidade do Estado do Rio de Janeiro · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

SARS-CoV-2 infection during pregnancy is not usually associated with significant adverse effects. However, in this study, we report a fetal death associated with mild COVID-19 in a 34-week-pregnant woman. The virus was detected in the placenta and in an unprecedented way in several fetal tissues. Placental abnormalities (MRI and anatomopathological study) were consistent with intense vascular malperfusion, probably the cause of fetal death. Lung histopathology also showed signs of inflammation, which could have been a contributory factor. Monitoring inflammatory response and coagulation in high-risk pregnant women with COVID-19 may prevent unfavorable outcomes, as shown in this case.

Indexed as

COVID-19fetal deathmother-to-child transmissionplacental thromboembolismpregnancySARS-CoV-2

Identifiers

PMID34485327
PMCPMC8415358
OpenAlexW3196267730

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.