Evidence map›Paper›PMID 34485142›Full record

ArticleFrontiers in oncology2021

Small RNA Sequencing Identifies PIWI-Interacting RNAs Deregulated in Glioblastoma-piR-9491 and piR-12488 Reduce Tumor Cell Colonies

Michael Bartos, Frantisek Siegl, Alena Kopkova, Lenka Radova, Jan Oppelt, Marek Vecera, Tomas Kazda, Radim Jancalek, Michal Hendrych, Marketa Hermanova and 10 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in oncology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed, 2 pooled it
0.8field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 2 syntheses or guidelines pooled it, 15 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors at 6 institutions in 1 country.

Michael BartosDepartment of Neurosurgery, University Hospital Hradec Kralove, Hradec Kralove, Czechia.
Frantisek SieglCentral European Institute of Technology, Masaryk University, Brno, Czechia.
Alena KopkovaCentral European Institute of Technology, Masaryk University, Brno, Czechia.
Lenka RadovaCentral European Institute of Technology, Masaryk University, Brno, Czechia.
Jan OppeltCentral European Institute of Technology, Masaryk University, Brno, Czechia.
Marek VeceraCentral European Institute of Technology, Masaryk University, Brno, Czechia.
Tomas KazdaDepartment of Radiation Oncology, Masaryk Memorial Cancer Institute and Medical Faculty, Masaryk University, Brno, Czechia.
Radim JancalekDepartment of Neurosurgery, St. Anne's University Hospital and Medical Faculty, Masaryk University, Brno, Czechia.
Michal Hendrych1st Department of Pathology, St. Anne's University Hospital and Medical Faculty, Masaryk University, Brno, Czechia.
Marketa Hermanova1st Department of Pathology, St. Anne's University Hospital and Medical Faculty, Masaryk University, Brno, Czechia.
Petra KasparovaThe Fingerland Department of Pathology, University Hospital Hradec Kralove, Hradec Kralove, Czechia.
Zuzana PleskacovaDepartment of Oncology and Radiotherapy, University Hospital Hradec Kralove, Hradec Kralove, Czechia.
Vaclav VybihalDepartment of Neurosurgery, University Hospital Brno, Brno, Czechia.
Pavel FadrusDepartment of Neurosurgery, University Hospital Brno, Brno, Czechia.
Martin SmrckaDepartment of Neurosurgery, University Hospital Brno, Brno, Czechia.
Radek LakomyDepartment of Comprehensive Cancer Care, Masaryk Memorial Cancer Institute, Brno, Czechia.
Radim LipinaDepartment of Neurosurgery, University Hospital Ostrava, Ostrava, Czechia.
Tomas CesakDepartment of Neurosurgery, University Hospital Hradec Kralove, Hradec Kralove, Czechia.
Ondrej SlabyCentral European Institute of Technology, Masaryk University, Brno, Czechia.
Jiri SanaCentral European Institute of Technology, Masaryk University, Brno, Czechia.
Central European Institute of Technology – Masaryk University · CZMasaryk University · CZUniversity Hospital Hradec Králové · CZUniversity Hospital Brno · CZMasaryk Memorial Cancer Institute · CZUniversity Hospital Ostrava · CZ

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Glioblastoma (GBM) is the most frequently occurring primary malignant brain tumor of astrocytic origin. To change poor prognosis, it is necessary to deeply understand the molecular mechanisms of gliomagenesis and identify new potential biomarkers and therapeutic targets. PIWI-interacting RNAs (piRNAs) help in maintaining genome stability, and their deregulation has already been observed in many tumors. Recent studies suggest that these molecules could also play an important role in the glioma biology. To determine GBM-associated piRNAs, we performed small RNA sequencing analysis in the discovery set of 19 GBM and 11 non-tumor brain samples followed by TaqMan qRT-PCR analyses in the independent set of 77 GBM and 23 non-tumor patients. Obtained data were subsequently bioinformatically analyzed. Small RNA sequencing revealed 58 significantly deregulated piRNA molecules in GBM samples in comparison with non-tumor brain tissues. Deregulation of piR-1849, piR-9491, piR-12487, and piR-12488 was successfully confirmed in the independent groups of patients and controls (all

Indexed as

diagnosisglioblastomapiRNAPIWI-interacting RNAprognosis

Identifiers

PMID34485142
PMCPMC8415021
OpenAlexW3193747274

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.