Evidence map›Paper›PMID 34485023›Full record

ArticleCurrent sleep medicine reports2021

Memory Consolidation Is Similar in Waking and Sleep.

Jerome M Siegel

Open access · greenAbstract read
In one paragraph

Article in Current sleep medicine reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.8field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 18 citations in OpenAlex.

  1. Sleep Patterns and Human Brain Health.The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry · 2025
    Review
  2. Article
  3. A 108-h total sleep deprivation did not impair fur seal performance in delayed matching to sample task.Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology · 2024
    Article
  4. Article
  5. Sleep preferentially consolidates negative aspects of human memory: Well-powered evidence from two large online experiments.Proceedings of the National Academy of Sciences of the United States of America · 2022
    Article
  6. Review
  7. Review
  8. Consolidation of Sleep-Dependent Appetitive Memory Is Mediated by a Sweet-Sensing Circuit.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2022
    Article
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

1 author at 1 institution in 1 country.

Jerome M SiegelNeuropsychiatric Institute and Brain Research Institute, University of California, Los Angeles, Los Angeles, CA 90095, USA.
VA Greater Los Angeles Healthcare System · US

Funding

Role of hypocretin in opiate addiction and withdrawalR01DA034748 · NIDA · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI SIEGEL, JEROME M · 2014 to 2024
$6.3M
Environmental determinants of human sleep timing, duration and continuity: studies in hunter gatherersR01HL148574 · NHLBI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI SIEGEL, JEROME M · 2019 to 2023
$3.6M
BLRD Senior Research Career Scientist Renewal ApplicationIK6BX005245 · VA · VA GREATER LOS ANGELES HEALTHCARE SYSTEM · PI SIEGEL, JEROME M · 2020 to 2025
–
BLRD VA I01 BX006214BLRD VA IK6 BX005245NHLBI NIH HHS R01 HL148574NIDA NIH HHS R01 DA034748
6 · The paper itself

Abstract

purpose of reviewI review the current status of the hypothesis that sleep is critically involved in memory consolidation and conclude that there are major methodological problems with the studies used to support this hypothesis. RECENT

findingsMemory consolidation is similar in quiet waking and sleep (Humiston GB, Tucker MA, Summer T, Wamsley EJ. Sci Rep 18;9(1):19345, 2019), and suppression of REM sleep for long periods is compatible with learning and highly adaptive behavior (Lyamin OI, Korneva SM, Obukhova ED, Mukhametov LM, Siegel JM. Dokl Biol Sci 463:211-4, 2015; Lyamin OI, Kosenko PO, Korneva SM, Vyssotski AL, Mukhametov LM, Siegel JM. Current Biology 28(12):2000-5, 2018); despite their considerable abilities to navigate and remember, African elephants have very small amount of sleep, and learning interference effects have not been adequately controlled for in studies purporting to show sleep-dependent memory consolidation (Sosic-Vasic Z, Hille K, Kroner J, Spitzer M, Kornmeier J. Frontiers in psychology 9:82, 2018; Yonelinas AP, Ranganath C, Ekstrom AD, Wiltgen BJ. Nat Rev Neurosci 20(6):364-75, 2019). SUMMARY: Memory consolidation clearly occurs in both sleep and waking. Whether, and the extent to which, consolidation might differ in these two states has not been conclusively determined.

Indexed as

ConsolidationLearningMemoryREM sleepSleepWaking

Identifiers

PMID34485023
PMCPMC8412129
OpenAlexW3119678405

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.