Evidence map›Paper›PMID 34484928›Full record

ArticleNeurology. Clinical practice2021

RCT of a Telehealth Group-Based Intervention to Increase Physical Activity in Multiple Sclerosis: eFIT.

Victoria M Leavitt, Ines M Aguerre, Nancy Lee, Claire S Riley, Philip L De Jager, Sharonna Bloom

Registry-linked trialOpen access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neurology. Clinical practice, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03829267 (eFIT), which is not on this map. Cited by 4 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed, 1 pooled it
0.8field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03829267 nacompletednot on this map

eFIT: An Internet-based Intervention to Increase Physical Activity in Persons With Multiple Sclerosis

TypeinterventionalSponsorColumbia UniversityRan2019 to 2020Enrolled44ConditionsMultiple SclerosisArmseFIT Intervention, eJournal Intervention, Treatment as usual
3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 1 synthesis or guideline pooled it, 8 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Victoria M LeavittTranslational Cognitive Neuroscience Laboratory (VML), Multiple Sclerosis Center (VML, IMA, CSR, PLDJ, SB), Center for Translational & Computational Neuroimmunology (IMA, CSR, PLDJ), Department of Neurology, Columbia University Irving Medical Center; and Department of Rehabilitation and Regenerative Medicine (NL), Columbia University Vagelos College of Physicians and Surgeons, New York.
Ines M AguerreTranslational Cognitive Neuroscience Laboratory (VML), Multiple Sclerosis Center (VML, IMA, CSR, PLDJ, SB), Center for Translational & Computational Neuroimmunology (IMA, CSR, PLDJ), Department of Neurology, Columbia University Irving Medical Center; and Department of Rehabilitation and Regenerative Medicine (NL), Columbia University Vagelos College of Physicians and Surgeons, New York.
Nancy LeeTranslational Cognitive Neuroscience Laboratory (VML), Multiple Sclerosis Center (VML, IMA, CSR, PLDJ, SB), Center for Translational & Computational Neuroimmunology (IMA, CSR, PLDJ), Department of Neurology, Columbia University Irving Medical Center; and Department of Rehabilitation and Regenerative Medicine (NL), Columbia University Vagelos College of Physicians and Surgeons, New York.
Claire S RileyTranslational Cognitive Neuroscience Laboratory (VML), Multiple Sclerosis Center (VML, IMA, CSR, PLDJ, SB), Center for Translational & Computational Neuroimmunology (IMA, CSR, PLDJ), Department of Neurology, Columbia University Irving Medical Center; and Department of Rehabilitation and Regenerative Medicine (NL), Columbia University Vagelos College of Physicians and Surgeons, New York.
Philip L De JagerTranslational Cognitive Neuroscience Laboratory (VML), Multiple Sclerosis Center (VML, IMA, CSR, PLDJ, SB), Center for Translational & Computational Neuroimmunology (IMA, CSR, PLDJ), Department of Neurology, Columbia University Irving Medical Center; and Department of Rehabilitation and Regenerative Medicine (NL), Columbia University Vagelos College of Physicians and Surgeons, New York.ORCID 0000-0002-8057-2505
Sharonna BloomTranslational Cognitive Neuroscience Laboratory (VML), Multiple Sclerosis Center (VML, IMA, CSR, PLDJ, SB), Center for Translational & Computational Neuroimmunology (IMA, CSR, PLDJ), Department of Neurology, Columbia University Irving Medical Center; and Department of Rehabilitation and Regenerative Medicine (NL), Columbia University Vagelos College of Physicians and Surgeons, New York.
Columbia University · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo conduct a pilot randomized controlled trial to determine whether participation in a group-based structured telehealth intervention increases physical activity in people with multiple sclerosis (MS).

methodsIn this parallel-arms trial, all study procedures were administered remotely. Adults diagnosed with MS (any subtype) were randomized to one of two 12-week (1 h/wk) active conditions: eFIT, online moderated structured groups; or eJournal, online independent journaling. For comparison, a treatment-as-usual (TAU; i.e., no eFIT/eJournal) group was enrolled. The primary outcome was feasibility (completion and adherence). The secondary efficacy outcomes included self-reported physical activity level (International Physical Activity Questionnaire, IPAQ).

resultsParticipants were 37 adults with MS. The sample was diverse: 66.7% female; age range 23-64 years; 17.5% Hispanic, 12.5% Black; and progressive and relapsing-remitting disease subtypes. Regarding feasibility, 70.7% completed; average adherence was 74.9%. Physical activity in active groups increased by 34.2% (baseline IPAQ = 2,406.8 ± 1,959.7, follow-up = 3,229.4 ± 2,575.2) and decreased in the TAU group by 17.4% (baseline = 2,519.9 ± 1,500.1, follow-up = 2,081.2 ± 1,814.9); group × time interaction was not statistically significant [F(2,25) = 1.467,

conclusionsTelehealth represents an accessible, acceptable vehicle to deliver targeted behavioral treatments to a neurologic population. eFIT may be an effective intervention for increasing physical activity, a historically intractable treatment target, in individuals with MS. In addition, these results provide evidence for feasibility of conducting fully remote clinical trial research. CLASSIFICATION OF EVIDENCE: This study provides Class II evidence that for people with MS, participation in a group-based structured telehealth intervention compared with TAU resulted in a (non-significant) increase in self-reported physical activity level. The percentage of participants who completed follow-up questionnaires did not differ between groups. The trial was registered at ClinicalTrials.gov (NCT03829267).

Identifiers

PMID34484928
PMCPMC8382401
OpenAlexW3123550584

What OpenQuestion holds

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Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.