Evidence map›Paper›PMID 34484896›Full record

ArticleNeurology. Clinical practice2021

Impact of Off Periods on Persons With Parkinson Disease and Care Partners: A Qualitative Study.

Melissa J Armstrong, Tara Rastgardani, Anna R Gagliardi, Connie Marras

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neurology. Clinical practice, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 1 pooled it
0.1field-weighted citation impact, top 52% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 1 synthesis or guideline pooled it, 8 citations in OpenAlex.

  1. Pooled it
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  4. Article
  5. Compound impact of cognitive and physical decline: A qualitative interview study of people with Parkinson's and cognitive impairment, caregivers and professionals.Health expectations : an international journal of public participation in health care and health policy · 2024
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Melissa J ArmstrongDepartment of Neurology (MJA), University of Florida College of Medicine, Gainesville; Morton and Gloria Shulman Movement Disorders Centre and the Edmond J Safra Program in Parkinson's Research (TR, CM), Toronto Western Hospital; and Toronto General Hospital Research Institute (ARG), University Health Network, Ontario, Canada.
Tara RastgardaniDepartment of Neurology (MJA), University of Florida College of Medicine, Gainesville; Morton and Gloria Shulman Movement Disorders Centre and the Edmond J Safra Program in Parkinson's Research (TR, CM), Toronto Western Hospital; and Toronto General Hospital Research Institute (ARG), University Health Network, Ontario, Canada.
Anna R GagliardiDepartment of Neurology (MJA), University of Florida College of Medicine, Gainesville; Morton and Gloria Shulman Movement Disorders Centre and the Edmond J Safra Program in Parkinson's Research (TR, CM), Toronto Western Hospital; and Toronto General Hospital Research Institute (ARG), University Health Network, Ontario, Canada.
Connie MarrasDepartment of Neurology (MJA), University of Florida College of Medicine, Gainesville; Morton and Gloria Shulman Movement Disorders Centre and the Edmond J Safra Program in Parkinson's Research (TR, CM), Toronto Western Hospital; and Toronto General Hospital Research Institute (ARG), University Health Network, Ontario, Canada.
Florida College · USUniversity of Florida · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe definition of off periods proposed in 2018 emphasizes functional disability as part of the off period experience, but limited research to date investigates the functional impact of off periods on persons with Parkinson disease and care partners. This study aimed to investigate the impact of off periods on both persons with Parkinson disease and care partners through interviews of dyads living with motor and/or nonmotor fluctuations.

methodsInvestigators performed interviews separately with persons with Parkinson disease and care partners using a semistructured questionnaire. Investigators used a qualitative descriptive approach to identify themes in interview transcripts relating to the impact of off periods on daily life. Identified themes were subsequently organized using World Health Organization quality of life domains.

resultsTwenty persons with Parkinson disease and their care partners (total n = 40) participated in interviews. Persons with Parkinson disease described impairments in level of independence (e.g., relating to employment, mobility, activities of daily living, and medication timing), socialization, leisure activities, driving, physical function, and psychological experiences relating to off periods. Care partners reported off period impacts on their own independence, socialization, leisure, and psychological experiences.

conclusionsClinicians should query the daily impact of off periods on both persons with Parkinson disease and care partners at clinical visits to inform treatment decisions and counseling. Measures of off period impact should be incorporated into clinical trials targeting fluctuations to fully understand the effects of interventions for fluctuations.

Identifiers

PMID34484896
PMCPMC8382372
OpenAlexW3082605517

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.