Evidence map›Paper›PMID 34484814›Full record

ArticleJournal of ophthalmology2021

Screening Evaporative Dry Eyes Severity Using an Infrared Image.

Qing Zhang, Yi Wu, Yilin Song, Guanghao Qin, Lanting Yang, Sumeet Singh Talwar, Tiezhu Lin, Gagan Deep Singh Talwar, Hongda Zhang, Ling Xu and 3 more

Registry-linked trialOpen access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of ophthalmology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06158997 (Safety and Effectiveness of EyePeace on Signs and Symptoms of Dry Eye Disease), which is not on this map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
2.4field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06158997 naunknown statusnot on this mapstarted 2023, after this paper: background citation

Safety and Effectiveness of EyePeace on Signs and Symptoms of Dry Eye Disease

TypeinterventionalSponsorHe Eye HospitalRan2023 to 2024Enrolled60ConditionsEvaporative Dry EyeArmsEyePeace, Heated Eye Mask
3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 20 citations in OpenAlex.

  1. Review
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  8. Observational
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 5 institutions in 2 countries.

Qing ZhangHe Eye Specialist Hospital, No. 128 North Huanghe Street, Shenyang, China.ORCID https://orcid.org/0000-0002-7777-6777
Yi WuHe Eye Specialist Hospital, No. 128 North Huanghe Street, Shenyang, China.
Yilin SongHe Eye Specialist Hospital, No. 128 North Huanghe Street, Shenyang, China.
Guanghao QinHe Eye Specialist Hospital, No. 128 North Huanghe Street, Shenyang, China.
Lanting YangHe Eye Specialist Hospital, No. 128 North Huanghe Street, Shenyang, China.
Sumeet Singh TalwarTianjin Medical University, Tianjin, China.
Tiezhu LinHe Eye Specialist Hospital, No. 128 North Huanghe Street, Shenyang, China.
Gagan Deep Singh TalwarTianjin Medical University, Tianjin, China.
Hongda ZhangHe Eye Specialist Hospital, No. 128 North Huanghe Street, Shenyang, China.
Ling XuHe Eye Specialist Hospital, No. 128 North Huanghe Street, Shenyang, China.ORCID https://orcid.org/0000-0002-7293-4983
Jonathan E MooreCathedral Eye Clinic, 89-91 Academy Street, Belfast, UK.ORCID https://orcid.org/0000-0002-3133-0825
Emmanuel Eric PazoHe Eye Specialist Hospital, No. 128 North Huanghe Street, Shenyang, China.ORCID https://orcid.org/0000-0002-0848-827X
Wei HeHe Eye Specialist Hospital, No. 128 North Huanghe Street, Shenyang, China.ORCID https://orcid.org/0000-0002-8024-1263
Dalian Medical University · CNHe Eye Hospital · CNTianjin Medical University · CNUniversity of Ulster · GBWenzhou Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundDry eye disease (DED) is a multifactorial and one of the most common problems treated in an ophthalmic outpatient clinic. Due to the variability in presentation, diagnosis of DED consists of a combination of subjective and objective clinical tests. The purpose of this study was to assess the effectiveness of a handheld smartphone-based infrared thermal (IRT) camera for screening symptomatic evaporative DED.

methodsThis observational sex-matched control study assessed IRT images of 184 right eyes (46 normal and 138 DED) of 184 participants. Evaporative DED was assessed using noninvasive tear breakup time, fluorescein staining, and the Chinese version of the ocular surface disease index (C-OSDI) questionnaire and categorized into their respective dry eye symptomology group (none, mild, moderate, or severe). The ocular surface temperature (OST) at 8 anatomical regions of interest (ROI) (nasal conjunctiva, nasal limbus, nasal cornea, central cornea, inferior cornea, temporal limbus, temporal cornea, and temporal conjunctiva) were measured and compared using a handheld smartphone-based IRT camera. The effectiveness of these 8 ROIs OST in detecting varying severity of DED was evaluated in terms of correlations with severity of DED and their area under the curve (AUC).

resultsOST at the 8 anatomical ROI was significantly higher in DED participants than in the non-DED group (

conclusionsRather than a diagnostic tool, handheld smartphone-based IRT images can be considered as a rapid, noninvasive, and hygienic screening tool in discriminating DED and non-DED and potentially alleviating inconvenience experienced during conventional tests.

Identifiers

PMID34484814
PMCPMC8410437
OpenAlexW3196115996

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.