ArticleApplied sciences (Basel, Switzerland)2019
Human Neural Stem Cells Flown into Space Proliferate and Generate Young Neurons.
Article in Applied sciences (Basel, Switzerland), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
What it found
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Who cites it
9 citing papers in PubMed.
- Influence of gravity variations on the activity of neuronal spheroids in an acoustic trap.NPJ microgravity · 2026Article
- Review
- Surface tension enables induced pluripotent stem cell culture in commercially available hardware during spaceflight.NPJ microgravity · 2024Article
- Discoveries from human stem cell research in space that are relevant to advancing cellular therapies on Earth.NPJ microgravity · 2024Review
- Influence of microgravity on spontaneous calcium activity of primary hippocampal neurons grown in microfluidic chips.NPJ microgravity · 2024Article
- Space Flight Enhances Stress Pathways in Human Neural Stem Cells.Biomolecules · 2024Article
- Metabolomic Profiling of the Secretome from Human Neural Stem Cells Flown into Space.Bioengineering (Basel, Switzerland) · 2023Article
- Delayed Maturation of Oligodendrocyte Progenitors by Microgravity: Implications for Multiple Sclerosis and Space Flight.Life (Basel, Switzerland) · 2022Article
- Effect of Microgravity Environment on Gut Microbiome and Angiogenesis.Life (Basel, Switzerland) · 2021Article
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
Here we demonstrate that human neural stem cells (NSCs) proliferate while in space and they express specific NSC markers after being in space. NSCs displayed both higher oxygen consumption and glycolysis than ground controls. These cells also kept their ability to become young neurons. Electrophysiological recordings of space NSC-derived neurons showed immature cell membrane properties characterized by small capacitance and very high input resistance. Current injections elicited only an incipient action potential. No spontaneous synaptic events could be detected, suggesting their immature status even though most recorded cells displayed complex morphology and numerous cell processes. Ascertaining the origin of the NSCs' increased energy requirement is of the essence in order to design effective measures to minimize health risks associated with long-duration human spaceflight missions.
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Registered trials
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