ArticleJournal of dental sciences2021
Metagenomic analysis of the salivary microbiota in patients with caries, periodontitis and comorbid diseases.
Article in Journal of dental sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.
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Who cites it
20 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Does high sugar intake really alter the oral microbiota?: A systematic review.Clinical and experimental dental research · 2022Pooled it
- Interindividual differences in acidogenic potential of the salivary microbiome after mouthwash exposure.BMC microbiology · 2026Article
- Salivary Biomarkers in Periodontal Disease: Revolutionizing Early Detection and Precision Dentistry.Molecular diagnosis & therapy · 2025Review
- Salivary microbiota profile in adult and children population according to active dentin caries: a metagenomic preliminary analysis.Frontiers in oral health · 2025Article
- Innovative strategies targeting oral microbial dysbiosis: unraveling mechanisms and advancing therapies for periodontitis.Frontiers in cellular and infection microbiology · 2025Review
- Oral Microbiota Development in the First 60 Months: A Longitudinal Study.Journal of dental research · 2024Article
- Effects of clear aligners and traditional removable appliances on oral microbiome in mixed dentition: a comparative study.BMC oral health · 2024Article
- Comparative analysis of microbial composition and functional characteristics in dental plaque and saliva of oral cancer patients.BMC oral health · 2024Article
- Alterations and correlations in dental plaque microbial communities and metabolome characteristics in patients with caries, periodontitis, and comorbid diseases.BMC oral health · 2024Article
- Characterization of pathogenic microbiome on removable prostheses with different levels of cleanliness using 2bRAD-M metagenomic sequencing.Journal of oral microbiology · 2024Article
- Exploring links between oral health and infective endocarditis.Frontiers in oral health · 2024Review
- Oral microbial dysbiosis in patients with periodontitis and chronic obstructive pulmonary disease.Frontiers in cellular and infection microbiology · 2023Article
- Next-Generation Examination, Diagnosis, and Personalized Medicine in Periodontal Disease.Journal of personalized medicine · 2022Review
- The Oral Microbiome Impacts the Link between Sugar Consumption and Caries: A Preliminary Study.Nutrients · 2022Article
- A potential oral microbiome signature associated with coronary artery disease in Tunisia.Bioscience reports · 2022Article
- Identification of the specific microbial community compositions in saliva associated with periodontitis during pregnancy.Clinical oral investigations · 2022Article
- Short-term head-down bed rest microgravity simulation alters salivary microbiome in young healthy men.Frontiers in microbiology · 2022Article
- Inflammatory response of gut, spleen, and liver in mice induced by orally administeredJournal of oral microbiology · 2022Article
- Oral and Gut Microbial Dysbiosis and Non-alcoholic Fatty Liver Disease: The Central Role ofFrontiers in medicine · 2022Review
- Healthy Oral Lifestyle Behaviours Are Associated with Favourable Composition and Function of the Oral Microbiota.Microorganisms · 2021Article
Corrections and comments
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
background/purposePrevious studies have suggested that there is a mutual antagonism between caries and periodontitis. This research aimed to investigate the ecological connection and bacterial interaction of these two diseases. MATERIALS AND
methodsWe profiled and analyzed the salivary microbiota from 124 individuals (including 38 caries patients, 34 periodontitis patients, 15 comorbid diseases patients, and 37 healthy controls) by using 16 S rRNA gene sequencing and bioinformatics approaches, and also quantified their salivary bacteria loads via quantitative real-time PCR. The putative biological functions of the salivary microbiome of the different groups were predicted by PICRUSt.
resultsWe observed that both the total bacteria loads and the overall microbial richness in the saliva of the periodontitis group were higher than that in the healthy group. The principal coordinate analysis (PCoA) showed that the caries, periodontitis and healthy groups were separated from each other, and that the samples from comorbid diseases were located at the overlap of caries and periodontitis groups. Using LEfSe analysis, 20 differentially abundant genera were identified as potential biomarkers. These genera also performed complicated interactions among the four groups. Additionally, the PICRUSt analysis indicated caries-related and periodontitis-related functions (e.g., carbohydrate metabolism and bacteria proliferation) respectively.
conclusionWe disclosed the significant differences in the salivary bacterial community under caries, periodontitis and comorbid diseases. The periodontitis group was marked by the increased complexity of the salivary microbiota. The result may have vital clinical significance to the screening and early treatment of caries-active and periodontitis-active individuals.
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