ArticleDisease markers2021
Albumin-Globulin Ratio Is an Independent Determinant of 28-Day Mortality in Patients with Critical Illness.
Article in Disease markers, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 1 of them a synthesis that pooled it.
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Who cites it
8 citing papers in PubMed, 1 synthesis or guideline pooled it, 15 citations in OpenAlex.
- Prognostic value of albumin-based indices for mortality after heart failure: a systematic review and meta-analysis.BMC cardiovascular disorders · 2024Pooled it
- Albumin-to-Globulin ratio as an independent risk factor for predicting prognostic risk in patients with acute coronary syndrome undergoing percutaneous coronary intervention.BMC cardiovascular disorders · 2025Article
- Association between serum albumin-to-globulin ratio and subtypes of cerebral atherosclerotic stenosis in acute ischemic stroke.Frontiers in neurology · 2025Article
- The association of serum albumin with 28 day mortality in critically ill patients undergoing dialysis: a secondary analysis based on the eICU collaborative research database.European journal of medical research · 2024Article
- A positive correlation between serum lactate dehydrogenase level and in-hospital mortality in ICU sepsis patients: evidence from two large databases.European journal of medical research · 2024Article
- Evaluation of endothelial glycocalyx injury biomarkers in feline hemotropic mycoplasmosis.Scientific reports · 2024Article
- A Case of Evans' Syndrome after Multiple Injuries and Septic Complications.Journal of emergencies, trauma, and shockArticle
- Usefulness of Evaluating the Albumin-to-globulin Ratio in Investigating the Etiology of Severe Hypokalemia.Journal of emergencies, trauma, and shockArticle
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundCritical illness in the intensive care unit (ICU) has been a global health priority. Systemic nutritional status has turned out to be related to the prognosis of critically ill patients. The albumin-globulin ratio (AGR) has been reported to be a novel prognostic factor of many diseases. This study is aimed at investigating whether the AGR could predict the mortality risk in critically ill patients.
methodsWe enrolled 582 adult patients admitted to the respiratory intensive care unit (RICU). We collected the clinical and laboratory data. X-tile software was used to determine the optimal cut-off values for the AGR. Patients were divided into three groups according to the AGR (low AGR group with AGR < 0.8, medium AGR group with AGR ranging from 0.8 to 1.1, and high AGR group with AGR > 1.1). Kaplan-Meier analysis was used for survival analysis. A Cox proportional hazard model was applied to the univariate and multivariate analyses for the potential predictors associated with survival.
resultsOur present study showed that the AGR was related to the 28-day survival of critically ill patients in the RICU. The rate of pneumonia in the low AGR group was significantly higher than that in the other groups. Patients with a lower AGR present an increased risk of 28-day mortality compared to patients with a higher AGR. Cox regression analysis showed that the AGR might be an independent predictor of prognosis to 28-day survival in critically ill patients in the RICU. Medium and high AGR values remained independently associated with better 28-day survival than low AGR values (HR: 0.484 (0.263-0.892) (
conclusionThe AGR might be an independent predictor of prognosis in critically ill patients.
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