Evidence map›Paper›PMID 34484412›Full record

ArticleVulnerable children and youth studies2021

"It was not okay because you leave your friends behind": A prospective analysis of transition to adult care for adolescents living with perinatally-acquired HIV in South Africa.

Brian C Zanoni, Moherndran Archary, Tamarra Subramony, Thobekile Sibaya, Christina Psaros, Jessica E Haberer

Open access · hybridAbstract read
In one paragraph

Article in Vulnerable children and youth studies, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed, 1 pooled it
4.7field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 1 synthesis or guideline pooled it, 30 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Trial
  4. Article
  5. Healthcare Transition From Pediatric to Adult Care Among Youth Living With HIV in South Carolina: Retrospective Study From 2005 to 2021.The Journal of adolescent health : official publication of the Society for Adolescent Medicine · 2026
    Article
  6. "AIDS care · 2026
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  18. Long-Term Post-Transition Outcomes of Adolescents and Young Adults Living With Perinatally and Non-perinatally Acquired HIV in Southeast Asia.The Journal of adolescent health : official publication of the Society for Adolescent Medicine · 2023
    Article
  19. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 4 institutions in 2 countries.

Brian C ZanoniEmory University, Atlanta, Georgia, United States of America.
Moherndran ArcharyUniversity of KwaZulu-Natal Nelson Mandela School of Medicine, Durban, South Africa.
Tamarra SubramonyMahatma Gandhi Hospital, KwaMashu, South Africa.
Thobekile SibayaUniversity of KwaZulu-Natal Nelson Mandela School of Medicine, Durban, South Africa.
Christina PsarosMassachusetts General Hospital, Boston, Massachusetts, United States of America.
Jessica E HabererMassachusetts General Hospital, Boston, Massachusetts, United States of America.
Harvard University · USUniversity of KwaZulu-Natal · ZAEmory University · USMahatma Gandhi Memorial Hospital · ZA

Funding

Harvard Clinical and Translational Science CenterKL2TR001100 · NCATS · HARVARD MEDICAL SCHOOL · PI NADLER, LEE MARSHALL · 2013 to 2017
$8.5M
Optimizing mHealth for adherence monitoring and interventionK24MH114732 · NIMH · MASSACHUSETTS GENERAL HOSPITAL · PI HABERER, JESSICA ELIZABETH · 2017 to 2021
$800k
NCATS NIH HHS KL2 TR001100NIMH NIH HHS K24 MH114732
6 · The paper itself

Abstract

objectiveTo determine facilitators and barriers to successful transition to adult care for adolescents living with perinatally-acquired HIV in South Africa.

methodsWe prospectively enrolled 30 adolescents living with perinatally-acquired HIV after their pediatrician deemed them ready for transition to adult care but prior to their transition. Eighteen months after enrollment, we measured transition status, engagement in care (i.e., viral load within 12 months of transition), and viral suppression (<200 copies/ml). Additionally, we conducted in-depth interviews with adolescents before and after transition to explore facilitators and barriers to successful transition.

resultsA total of 19/30 (63%) adolescents transitioned to adult care. Of those who transitioned, 11 (58%) were retained in care and 7 (37%) were virally suppressed one year after transition to adult care. Insufficient staff training, lack of availability of pediatric ART formulations in adult clinics, and insufficient clinical monitoring contributed to delayed transition. Rigid clinical scheduling that interfered with school and loss of clinic relationships with peers and clinical staff were major factors in contributing to poor engagement in care after transition. Maturity of the adolescent, reduced distance to clinic, and reduced length of time in the clinic were seen as facilitators to transition to adult care.

conclusionImproved preparation for transition by pediatric and adult clinical staff, including restructuring of care delivery, may improve successful transition of adolescents living with perinatally acquired HIV to adult care. Transition readiness assessments are needed to determine optimal timing of transition and which adolescents are ready to transition to adult care.

Indexed as

AdolescentHIVSouth Africatransition in care

Identifiers

PMID34484412
PMCPMC8414445
OpenAlexW3125531842

What OpenQuestion holds

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LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.