ArticleFrontiers in genetics2021
Development and Validation of a Forensic Multiplex System With 38 X-InDel Loci.
Article in Frontiers in genetics, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed.
- Large-scale human genomic resources drive innovations toward forensic intelligent source attribution and precision identification.International journal of legal medicine · 2026Review
- Developmental validation of a novel all-in one assay of X chromosomal multi-insertion/deletion loci for forensic genetics.Scientific reports · 2024Article
- Article
- Developmental validation of a novel multiple genotyping assay with 24 Canine STR loci.The veterinary quarterly · 2023Article
- Article
- Review
- Applications of massively parallel sequencing in forensic genetics.Genetics and molecular biology · 2022Article
- An Application of ITO Analysis in Secondary Kinship Identification.Computational and mathematical methods in medicine · 2022Article
- Forensic efficiencies of individual identification, kinship testing and ancestral inference in three Yunnan groups based on a self-developed multiple DIP panel.Frontiers in genetics · 2022Article
- Development and Performance Evaluation of a Novel Ancestry Informative DIP Panel for Continental Origin Inference.Frontiers in genetics · 2021Article
- Genetic Structure and Forensic Feature of 38 X-Chromosome InDels in the Henan Han Chinese Population.Frontiers in genetics · 2021Article
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Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In the present study, a novel multiplex system, AGCU X-InDel 38 kit, was designed to amplify 38 X-InDel markers and amelogenin in a single Polymerase Chain Reaction (PCR). To demonstrate the suitability and efficiency for forensic applications, a series of validation experiments were conducted, including sensitivity, species specificity, reproducibility, stability, case samples, balance of peak height, size precision, as well as allele frequency and forensic parameter analysis. The results showed that AGCU X-InDel 38 kit was capable to get full profiles even with 62.5 pg of template DNA, and full profiles can be obtained when hematin concentration ≤25 μmol/L, or hemoglobin concentration ≤50 μmol/L, showing good tolerance to six common inhibitors. Moreover, the analyzed case samples indicated that AGCU X-InDel 38 kit had better performance for degraded and trace DNA samples. The 200 unrelated males from Guangdong Han population showed that the combined PD
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