Evidence map›Paper›PMID 34484215›Full record

ArticleFrontiers in immunology2021

Group 2 Innate Lymphoid Cells Exhibit Tissue-Specific Dynamic Behaviour During Type 2 Immune Responses.

Laurence S C Lok, Jennifer A Walker, Helen E Jolin, Seth T Scanlon, Masaru Ishii, Padraic G Fallon, Andrew N J McKenzie, Menna R Clatworthy

Open access · goldAbstract readVideo-Audio Media
In one paragraph

Article in Frontiers in immunology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.8field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 12 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 5 institutions in 3 countries.

Laurence S C LokMolecular Immunity Unit, Department of Medicine, MRC Laboratory of Molecular Biology, University of Cambridge, Cambridge, United Kingdom.
Jennifer A WalkerMedical Research Council Laboratory of Molecular Biology, Cambridge, United Kingdom.
Helen E JolinMedical Research Council Laboratory of Molecular Biology, Cambridge, United Kingdom.
Seth T ScanlonMedical Research Council Laboratory of Molecular Biology, Cambridge, United Kingdom.
Masaru IshiiDepartment of Immunology and Cell Biology, Graduate School of Medicine, Osaka University, Osaka, Japan.
Padraic G FallonSchool of Medicine, Trinity College Dublin, Dublin, Ireland.
Andrew N J McKenzieMedical Research Council Laboratory of Molecular Biology, Cambridge, United Kingdom.
Menna R ClatworthyMolecular Immunity Unit, Department of Medicine, MRC Laboratory of Molecular Biology, University of Cambridge, Cambridge, United Kingdom.
Medical Research Council · GBMRC Laboratory of Molecular Biology · GBUniversity of Cambridge · GBOsaka University · JPTrinity College Dublin · IE

Funding

Medical Research Council MR/N024907/1Medical Research Council U105178805Wellcome Trust 100963/Z/13/ZWellcome Trust 104384/Z/14/Z
6 · The paper itself

Abstract

Group 2 innate lymphoid cells (ILC2s) are early effectors of mucosal type 2 immunity, producing cytokines such as interleukin (IL)-13 to mediate responses to helminth infection and allergen-induced inflammation. ILC2s are also present in lymph nodes (LNs) and can express molecules required for antigen presentation, but to date there are limited data on their dynamic behaviour. We used a CD2/IL-13 dual fluorescent reporter mouse for

Indexed as

NippostrongylusAnimalsGenes, ReporterInterleukin-13Intestinal Diseases, ParasiticIntestinal MucosaIntestine, SmallIntravital MicroscopyLymphocyte CountLymphocyte SubsetsMiceOrgan SpecificitySchistosomiasis mansoniSpecific Pathogen-Free OrganismsStrongylida InfectionsTh2 CellsInterleukin-13Innate lymphoid cellintravital imaginglymph nodemucosatype 2 inflammation

Identifiers

PMID34484215
PMCPMC8415880
OpenAlexW3196114187

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.