Evidence map›Paper›PMID 34484178›Full record

ArticleFrontiers in immunology2021

Prostaglandin E2 Signaling Mediates Oenocytoid Immune Cell Function and Lysis, Limiting Bacteria and

Hyeogsun Kwon, David R Hall, Ryan C Smith

Open access · goldAbstract read
In one paragraph

Article in Frontiers in immunology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
1.4field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 29 citations in OpenAlex.

  1. Review
  2. Review
  3. The Fat Body: Structure and Functions.Advances in experimental medicine and biology · 2026
    Review
  4. Insect Lipids: Structure, Classification and Function.Advances in experimental medicine and biology · 2026
    Review
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Review
  11. Article
  12. Review
  13. TheProceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  14. Article
  15. Review
  16. Evolution and assembly ofOpen biology · 2023
    Article
  17. Article
  18. Review
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Hyeogsun KwonDepartment of Entomology, Iowa State University, Ames, IA, United States.
David R HallDepartment of Entomology, Iowa State University, Ames, IA, United States.
Ryan C SmithDepartment of Entomology, Iowa State University, Ames, IA, United States.
Iowa State University · US

Funding

Eicosanoid regulation of mosquito innate immunityR21AI144705 · NIAID · IOWA STATE UNIVERSITY · PI SMITH, RYAN C. · 2019 to 2020
$421k
NIAID NIH HHS R21 AI144705
6 · The paper itself

Abstract

Lipid-derived signaling molecules known as eicosanoids have integral roles in mediating immune and inflammatory processes across metazoans. This includes the function of prostaglandins and their cognate G protein-coupled receptors (GPCRs) to employ their immunological actions. In insects, prostaglandins have been implicated in the regulation of both cellular and humoral immune responses, yet in arthropods of medical importance, studies have been limited. Here, we describe a prostaglandin E2 receptor (

Indexed as

Signal TransductionAnimalsAnophelesDinoprostoneHemocytesHost-Pathogen InteractionsImmunity, InnateMicrobial ViabilityMosquito VectorsOocystsPhylogenyPlasmodiumPore Forming Cytotoxic ProteinsReceptors, Prostaglandin EDinoprostonePore Forming Cytotoxic ProteinsReceptors, Prostaglandin Ehemocytesmosquito immunityoenocytoid rupturePGE2 receptorPGE2 signalingPlasmodiumprophenoloxidases

Identifiers

PMID34484178
PMCPMC8415482
OpenAlexW3195457818

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.