Evidence map›Paper›PMID 34484096›Full record

ArticleFrontiers in neurology2021

Pilot Safety and Feasibility Study of Non-invasive Limb Proprioceptive Cerebellar Stimulation for Epilepsy.

Ronald M Harper, Dieter Hertling, Ashley Curtis, Eberhardt K Sauerland, Christopher M De Giorgio

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in neurology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.2field-weighted citation impact, top 43% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 1 country.

Ronald M HarperDepartment of Neurobiology, David Geffen School of Medicine, Univeersity of California, Los Angeles, Los Angeles, CA, United States.
Dieter HertlingDepartment of Neurology, Olive View Medical Center, University of California, Los Angeles, Los Angeles, CA, United States.
Ashley CurtisDepartment of Neurology, Olive View Medical Center, University of California, Los Angeles, Los Angeles, CA, United States.
Eberhardt K SauerlandDepartment of Physiology, University of Nevada, Reno, NV, United States.
Christopher M De GiorgioDepartment of Neurology, Olive View Medical Center, University of California, Los Angeles, Los Angeles, CA, United States.
Olive View-UCLA Medical Center · USUniversity of California, Los Angeles · USUniversity of Nevada, Reno · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cerebellar stimulation reduces seizures in animals and in humans with drug-resistant epilepsy. In a pilot safety and feasibility study, we applied continuous cutaneous vibratory stimulation (limb proprioceptive cerebellar stimulation) to foot limb proprioceptive receptors to activate cerebellar, pontine, and thalamic structures in drug-resistant epilepsy patients for 8-h nocturnally up to 6-months after a 4-week pre-treatment control baseline. Seizure frequency was evaluated during the baseline control period, and at 6, 12, and 24 weeks after the control recordings. Five-subjects completed at least the first 6-week treatment. At 12-weeks, the median reduction in seizure frequency was -27.8% (mean reduction = -22.3%). Two subjects continued for 24 weeks, with a decline of -44.1 and -45.4%. This pilot study provides support for further clinical studies into the safety and efficacy of limb proprioceptive cerebellar stimulation for epilepsy.

Indexed as

cerebellumepilepsyneuromodulationneurostimulationproprioceptionseizuresSUDEPvibration

Identifiers

PMID34484096
PMCPMC8415900
OpenAlexW3193693365

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.