Evidence map›Paper›PMID 34483974›Full record

ArticleFrontiers in physiology2021

Glutamate 73 Promotes Anti-arrhythmic Effects of Voltage-Dependent Anion Channel Through Regulation of Mitochondrial Ca

Hirohito Shimizu, Simon Huber, Adam D Langenbacher, Lauren Crisman, Jie Huang, Kevin Wang, Fabiola Wilting, Thomas Gudermann, Johann Schredelseker, Jau-Nian Chen

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in physiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.5field-weighted citation impact, top 38% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 8 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
  4. Article
  5. STING Suppresses Mitochondrial VDAC2 to Govern RCC Growth Independent of Innate Immunity.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2023
    Article
  6. Review
  7. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 2 countries.

Hirohito ShimizuDepartment of Molecular, Cell and Developmental Biology, University of California, Los Angeles, Los Angeles, CA, United States.
Simon HuberWalther Straub Institute of Pharmacology and Toxicology, Faculty of Medicine, LMU Munich, Munich, Germany.
Adam D LangenbacherDepartment of Molecular, Cell and Developmental Biology, University of California, Los Angeles, Los Angeles, CA, United States.
Lauren CrismanDepartment of Molecular, Cell and Developmental Biology, University of California, Los Angeles, Los Angeles, CA, United States.
Jie HuangDepartment of Molecular, Cell and Developmental Biology, University of California, Los Angeles, Los Angeles, CA, United States.
Kevin WangDepartment of Molecular, Cell and Developmental Biology, University of California, Los Angeles, Los Angeles, CA, United States.
Fabiola WiltingWalther Straub Institute of Pharmacology and Toxicology, Faculty of Medicine, LMU Munich, Munich, Germany.
Thomas GudermannWalther Straub Institute of Pharmacology and Toxicology, Faculty of Medicine, LMU Munich, Munich, Germany.
Johann SchredelsekerWalther Straub Institute of Pharmacology and Toxicology, Faculty of Medicine, LMU Munich, Munich, Germany.
Jau-Nian ChenDepartment of Molecular, Cell and Developmental Biology, University of California, Los Angeles, Los Angeles, CA, United States.
University of California, Los Angeles · USLudwig-Maximilians-Universität München · DE

Funding

Rtf1-dependent transcriptional regulation of heart developmentR01HL140472 · NHLBI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI CHEN, JAU-NIAN, TRINH, LE A. · 2018 to 2021
$1.6M
Elucidating the molecular mechanisms regulating embryonic cardiac rhythmicityR01HL096980 · NHLBI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI CHEN, JAU-NIAN · 2010 to 2013
$1.5M
NHLBI NIH HHS R01 HL096980NHLBI NIH HHS R01 HL140472
6 · The paper itself

Abstract

Mitochondria critically regulate a range of cellular processes including bioenergetics, cellular metabolism, apoptosis, and cellular Ca

Indexed as

calciumcardiac rhythmicitymitochondriavoltage-dependent anion channelzebrafish

Identifiers

PMID34483974
PMCPMC8416314
OpenAlexW3193770639

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.