Evidence map›Paper›PMID 34483871›Full record

ArticleFrontiers in neuroinformatics2021

Clinica: An Open-Source Software Platform for Reproducible Clinical Neuroscience Studies.

Alexandre Routier, Ninon Burgos, Mauricio Díaz, Michael Bacci, Simona Bottani, Omar El-Rifai, Sabrina Fontanella, Pietro Gori, Jérémy Guillon, Alexis Guyot and 14 more

Open access · goldAbstract read
In one paragraph

Article in Frontiers in neuroinformatics, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
41citing papers in PubMed, 1 pooled it
12.1field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

41 citing papers in PubMed, 1 synthesis or guideline pooled it, 125 citations in OpenAlex.

  1. Pooled it
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  5. Composite grey matter fingerprints for genetic frontotemporal dementia.Journal of neurology, neurosurgery, and psychiatry · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

24 authors at 2 institutions in 1 country.

Alexandre RoutierInria, Aramis Project-Team, Paris, France.
Ninon BurgosInria, Aramis Project-Team, Paris, France.
Mauricio DíazInria, Service d'Expérimentation et de Développement, Paris, France.
Michael BacciInria, Aramis Project-Team, Paris, France.
Simona BottaniInria, Aramis Project-Team, Paris, France.
Omar El-RifaiInria, Aramis Project-Team, Paris, France.
Sabrina FontanellaInria, Aramis Project-Team, Paris, France.
Pietro GoriInria, Aramis Project-Team, Paris, France.
Jérémy GuillonInria, Aramis Project-Team, Paris, France.
Alexis GuyotInria, Aramis Project-Team, Paris, France.
Ravi HassanalyInria, Aramis Project-Team, Paris, France.
Thomas JacquemontInria, Aramis Project-Team, Paris, France.
Pascal LuInria, Aramis Project-Team, Paris, France.
Arnaud MarcouxInria, Aramis Project-Team, Paris, France.
Tristan MoreauSorbonne Université, Paris, France.
Jorge Samper-GonzálezInria, Aramis Project-Team, Paris, France.
Marc TeichmannSorbonne Université, Paris, France.
Elina Thibeau-SutreInria, Aramis Project-Team, Paris, France.
Ghislain VaillantInria, Aramis Project-Team, Paris, France.
Junhao WenInria, Aramis Project-Team, Paris, France.
Adam WildInria, Aramis Project-Team, Paris, France.
Marie-Odile HabertSorbonne Université, CNRS, INSERM, Laboratoire d'Imagerie Biomédicale (LIB), Paris, France.
Stanley DurrlemanInria, Aramis Project-Team, Paris, France.
Olivier ColliotInria, Aramis Project-Team, Paris, France.
Centre National de la Recherche Scientifique · FRInstitut national de recherche en sciences et technologies du numérique · FR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We present Clinica (www.clinica.run), an open-source software platform designed to make clinical neuroscience studies easier and more reproducible. Clinica aims for researchers to (i) spend less time on data management and processing, (ii) perform reproducible evaluations of their methods, and (iii) easily share data and results within their institution and with external collaborators. The core of Clinica is a set of automatic pipelines for processing and analysis of multimodal neuroimaging data (currently, T1-weighted MRI, diffusion MRI, and PET data), as well as tools for statistics, machine learning, and deep learning. It relies on the brain imaging data structure (BIDS) for the organization of raw neuroimaging datasets and on established tools written by the community to build its pipelines. It also provides converters of public neuroimaging datasets to BIDS (currently ADNI, AIBL, OASIS, and NIFD). Processed data include image-valued scalar fields (e.g., tissue probability maps), meshes, surface-based scalar fields (e.g., cortical thickness maps), or scalar outputs (e.g., regional averages). These data follow the ClinicA Processed Structure (CAPS) format which shares the same philosophy as BIDS. Consistent organization of raw and processed neuroimaging files facilitates the execution of single pipelines and of sequences of pipelines, as well as the integration of processed data into statistics or machine learning frameworks. The target audience of Clinica is neuroscientists or clinicians conducting clinical neuroscience studies involving multimodal imaging, and researchers developing advanced machine learning algorithms applied to neuroimaging data.

Indexed as

data processing and analysismachine learningmultimodal neuroimaging dataneuroimagingpipelinesoftware

Identifiers

PMID34483871
PMCPMC8415107
OpenAlexW2795552972

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.