ArticleCurrent directions in psychological science2021
The profound heterogeneity of substance use disorders: Implications for treatment development.
Article in Current directions in psychological science, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
37 citing papers in PubMed, 2 syntheses or guidelines pooled it, 50 citations in OpenAlex.
- Integrating Psychosocial Factors into Artificial Intelligence Models for Predicting Addiction Treatment Outcomes: A Systematic Review.European addiction research · 2026Pooled it
- Parameter Space and Potential for Biomarker Development in 25 Years of fMRI Drug Cue Reactivity: A Systematic Review.JAMA psychiatry · 2024Pooled it
- Alcohol abstinence precipitates alcohol seeking and aversion-resistant intake in association with increased BNST activity.Molecular psychiatry · 2026Article
- Heterogeneous structural brain signatures of methamphetamine and ketamine use disorders revealed by normative modeling.Molecular psychiatry · 2026Article
- Article
- Individualized prediction of heroin cue-induced craving using task-based EEG functional connectivity.NPJ digital medicine · 2026Article
- Neurobiological subtypes in alcohol use disorder and their phenotypic and clinical profiles.Molecular psychiatry · 2026Article
- Individual differences in ethanol drinking meal structure are shaped by social environments.bioRxiv : the preprint server for biology · 2026Article
- Normative modeling reveals functional connectivity heterogeneity in internet gaming disorder.Annals of general psychiatry · 2026Article
- Article
- Validation of the Observational Assessment Tool for Tailoring (OATT).Prevention science : the official journal of the Society for Prevention Research · 2026Article
- Association between GLP-1 receptor agonist use and substance use disorders among individuals with type 2 diabetes or obesity: a nested case-control study in the All of Us research program.Frontiers in psychiatry · 2026Article
- Fight, Flight, Fawn, Freeze: Rethinking Substance Use Through a Stress Response Lens.Current addiction reports · 2026Review
- Personalizing ecological momentary intervention for substance use disorders through data-driven decision rules.Frontiers in psychiatry · 2026Review
- Motives for Cannabis Use and Readiness to Change Among Users of the "Stop-Cannabis" Mobile App: Cluster Analysis.JMIR formative research · 2025Article
- Advancing future research on sepsis outcomes in adolescents with SUD: integrating AI, accounting for temporal trends, and enhancing exposure classification.Annals of intensive care · 2025Article
- "The hardest part of what we're doing": research staff perspectives on engaging marginalized populations in substance use trials.Substance abuse treatment, prevention, and policy · 2025Article
- Shared orbitofrontal dynamics to a drug-themed movie track craving and recovery in heroin addiction.Brain : a journal of neurology · 2025Article
- Subgroups of anxiety and depression trajectories during early abstinence in alcohol use disorder.Alcohol, clinical & experimental research · 2025Article
- Phenome-wide diagnostic comparison among suicide deaths and living individuals with chronic pain diagnoses.BMC medicine · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
Abstract
A single treatment approach will never be sufficient to address the diversity of individuals with substance use disorders (SUDs). SUDs have historically defied definition through simple characterizations or models, and no single characterization has led to the development of broadly effective interventions. The range of dimensions of heterogeneity among individuals with SUDs, including severity, type of substance, and issues that frequently co-occur underscore that highly tailored approaches are needed. To approach personalized medicine for individuals with SUDs; two major developments are needed. First, given the diversity of individuals with SUDs, multivariate phenotyping approaches are needed to identify the particular features driving addictive processes in any individual. Second, a wider range of interventions that directly target core mechanisms of addiction and the problems that co-occur with them are needed. As clinicians cannot be expected to master the full range of interventions that may target these core processes, developing these so that they can be delivered easily, flexibly, and systematically via technology will facilitate our ability to truly tailor interventions to this highly complex and challenging population. One such technology-delivered intervention, computer-based training for cognitive behavioral therapy (CBT4CBT), is used as an example to illustrate a vision for the future of highly-tailored interventions for individuals with SUDs.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.