Evidence map›Paper›PMID 34483486›Full record

ArticleMaterials science & engineering. R, Reports : a review journal2021

Collagen- and hyaluronic acid-based hydrogels and their biomedical applications.

Qinghua Xu, Jessica E Torres, Mazin Hakim, Paulina M Babiak, Pallabi Pal, Carly M Battistoni, Michael Nguyen, Alyssa Panitch, Luis Solorio, Julie C Liu

Abstract read
In one paragraph

Article in Materials science & engineering. R, Reports : a review journal, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 107 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
107citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

107 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Review
  3. Article
  4. Fish Collagen Hydrolysates in Wound Healing: A Patent Review.ACS pharmacology & translational science · 2026
    Review
  5. Article
  6. Article
  7. Review
  8. The Digestive System of the Greater Weever (International journal of molecular sciences · 2026
    Article
  9. Review
  10. Assessment of Bovine Collagen Manufactured via Cellular Agriculture.ACS biomaterials science & engineering · 2026
    Article
  11. Review
  12. Article
  13. Review
  14. Article
  15. Review
  16. Article
  17. Review
  18. Review
  19. Article
  20. Review

47 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Qinghua XuDavidson School of Chemical Engineering, Purdue University, West Lafayette, Indiana 47907, United States.
Jessica E TorresDavidson School of Chemical Engineering, Purdue University, West Lafayette, Indiana 47907, United States.
Mazin HakimWeldon School of Biomedical Engineering, Purdue University, West Lafayette, Indiana 47907, USA.
Paulina M BabiakDavidson School of Chemical Engineering, Purdue University, West Lafayette, Indiana 47907, United States.
Pallabi PalDavidson School of Chemical Engineering, Purdue University, West Lafayette, Indiana 47907, United States.
Carly M BattistoniDavidson School of Chemical Engineering, Purdue University, West Lafayette, Indiana 47907, United States.
Michael NguyenDepartment of Biomedical Engineering, University of California Davis, Davis, California 95616, United States.
Alyssa PanitchDepartment of Biomedical Engineering, University of California Davis, Davis, California 95616, United States.
Luis SolorioWeldon School of Biomedical Engineering, Purdue University, West Lafayette, Indiana 47907, USA.
Julie C LiuDavidson School of Chemical Engineering, Purdue University, West Lafayette, Indiana 47907, United States.

Funding

Training Program In Basic & Translational Cardiovascular ScienceT32HL086350 · NHLBI · UNIVERSITY OF CALIFORNIA AT DAVIS · PI Martin Cadeiras, David A. Liem · 2008 to 2026
$7.1M
NHLBI NIH HHS T32 HL086350
6 · The paper itself

Abstract

Hydrogels have been widely investigated in biomedical fields due to their similar physical and biochemical properties to the extracellular matrix (ECM). Collagen and hyaluronic acid (HA) are the main components of the ECM in many tissues. As a result, hydrogels prepared from collagen and HA hold inherent advantages in mimicking the structure and function of the native ECM. Numerous studies have focused on the development of collagen and HA hydrogels and their biomedical applications. In this extensive review, we provide a summary and analysis of the sources, features, and modifications of collagen and HA. Specifically, we highlight the fabrication, properties, and potential biomedical applications as well as promising commercialization of hydrogels based on these two natural polymers.

Indexed as

dynamic propertiesextracellular matrixFabricationMicrostructuresemi-interpenetrating network

Identifiers

PMID34483486
PMCPMC8409465

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.