Evidence map›Paper›PMID 34483137›Full record

ArticleAging2021

Hsa-circ-0007292 promotes the osteogenic differentiation of posterior longitudinal ligament cells via regulating SATB2 by sponging miR-508-3p.

Anlong Jiang, Nanxiang Wang, Xinxing Yan, Yunheng Jiang, Chengchao Song, Hui Chi, Guanghua Chen, Feng Wu, Ye Ji, Jinglong Yan

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Aging, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.6field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 8 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
  4. Article
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Anlong JiangDepartment of Orthopedics, The Second Affiliated Hospital of Harbin Medical University, Harbin, China.
Nanxiang WangDepartment of Orthopedics, The Second Affiliated Hospital of Harbin Medical University, Harbin, China.
Xinxing YanDepartment of Orthopedics, The Second Affiliated Hospital of Harbin Medical University, Harbin, China.
Yunheng JiangDepartment of Orthopedics, The Second Affiliated Hospital of Harbin Medical University, Harbin, China.
Chengchao SongDepartment of Orthopedics, The Second Affiliated Hospital of Harbin Medical University, Harbin, China.
Hui ChiDepartment of Orthopedics, The Second Affiliated Hospital of Harbin Medical University, Harbin, China.
Guanghua ChenDepartment of Orthopedics, The Second Affiliated Hospital of Harbin Medical University, Harbin, China.
Feng WuDepartment of Orthopedics, The Second Affiliated Hospital of Harbin Medical University, Harbin, China.
Ye JiDepartment of Orthopedics, The Second Affiliated Hospital of Harbin Medical University, Harbin, China.
Jinglong YanDepartment of Orthopedics, The Second Affiliated Hospital of Harbin Medical University, Harbin, China.
Second Affiliated Hospital of Harbin Medical University · CNHarbin Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Ossification of the posterior longitudinal ligament (OPLL) is a disorder with multiple pathogenic mechanisms and leads to different degrees of neurological symptoms. Recent studies have revealed that non-coding RNA (ncRNA), including long non-coding RNAs (lncRNAs) and microRNAs (miRNAs), could influence the development of OPLL. Nevertheless, the molecular mechanisms linking circular RNAs (circRNAs) and the progression of OPLL is still unknown. The current research explored the expression profiles of OPLL-related circRNAs by microarray analysis, and applied qRT-PCR to validate the results. Subsequently, we confirmed the upregulation of hsa_circ_0007292 in OPLL cells by qRT-PCR and validated the circular characteristic of hsa_circ_0007292 by Sanger sequencing. Fluorescence

Indexed as

OsteogenesisCell Line, TumorCell ProliferationHumansLongitudinal LigamentsMatrix Attachment Region Binding ProteinsMicroRNAsOssification of Posterior Longitudinal LigamentRNA, CircularTranscription FactorsUp-RegulationMatrix Attachment Region Binding ProteinsMicroRNAsMIRN508 microRNA, humanRNA, CircularSATB2 protein, humanTranscription FactorsceRNAcircRNAossificationosteogenic differentiationposterior longitudinal ligament

Identifiers

PMID34483137
PMCPMC8436939
OpenAlexW3194035478

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.