ArticleEuroIntervention : journal of EuroPCR in collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology2022
Transcatheter edge-to-edge mitral valve repair in patients with mitral annulus calcification.
Article in EuroIntervention : journal of EuroPCR in collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 25 citations in OpenAlex.
- Evolution of Clinical Indications for Mitral Valve Transcatheter Edge-to-Edge Repair.Reviews in cardiovascular medicine · 2026Review
- Transcatheter mitral valve options for severe mitral annular calcification.Annals of cardiothoracic surgery · 2025Review
- Early and mid-term outcomes of mitral annular calcification and transcatheter mitral therapy: a systematic review.Annals of cardiothoracic surgery · 2025Article
- Prognostic significance of mitral annular calcification assessed by computed tomography for transcatheter edge-to-edge repair outcomes.EuroIntervention : journal of EuroPCR in collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology · 2025Observational
- Mitral Annular Calcification: Understanding the Disease and Treatment Options.Structural heart : the journal of the Heart Team · 2025Review
- Mitral annular calcification in interventional cardiology: address all fears.AsiaIntervention · 2025Review
- Mitral Annular Calcification, a Not So Marginal and Relatively Benign Finding as Many of Us Think: A Review.Journal of cardiovascular development and disease · 2025Review
- Interventional therapies for chronic heart failure: An overview of recent developments.ESC heart failure · 2025Review
- Rheumatic and Degenerative Mitral Stenosis: From an Iconic Clinical Case to the Literature Review.Journal of cardiovascular development and disease · 2024Review
- Mitral Annular Calcification-Related Valvular Disease: A Challenging Entity.Journal of clinical medicine · 2024Review
- Current techniques for severe mitral annular calcification.JTCVS techniques · 2023Article
- Transcatheter Mitral Valve Replacement Using Transcatheter Aortic Valve or Dedicated Devices: Current Evidence and Future Prospects.Journal of clinical medicine · 2023Review
- Feasibility and Outcomes of Mitral Transcatheter Edge-To-Edge Repair in Patients With Variable Degrees of Mitral Annular Calcification.Journal of the American Heart Association · 2023Article
- Mitral Interventions in Heart Failure.JACC. Heart failure · 2023Review
- Early outcomes of transcatheter mitral valve replacement with the Tendyne system in severe mitral annular calcification.EuroIntervention : journal of EuroPCR in collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology · 2022Article
- Caseous Calcification of the Mitral Annulus Associated with Severe Mitral Regurgitation: A Multimodality Diagnostic Approach.Journal of cardiovascular echographyArticle
Corrections and comments
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Authors and funding
19 authors at 8 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundMAC is commonly found in patients affected with MR, and it is associated with high morbidity, mortality and worse cardiac surgical outcomes. Transcatheter edge-to-edge repair could be an alternative treatment, although there is little evidence in this population.
aimsThe aim of this study was to analyse the safety, efficacy and durability of MitraClip implantation in patients affected with mitral regurgitation (MR) and mitral annulus calcification (MAC).
methodsWe analysed the outcomes of 61 suitable patients affected with severe MR and moderate or severe MAC (the "MAC" group) and 791 patients with no or mild MAC (the "NoMAC" group) treated with the MitraClip device.
resultsProcedural success was similar (91.8% vs 95.1%, p=0.268, in MAC and NoMAC, respectively), with a very low rate of complications. At one-year follow-up, 90.6% of MAC and 79.5% of NoMAC patients had MR grade ≤2 (p=0.129), 80% in both groups remained in NYHA Functional Class ≤II, and a significant reduction in cardiac readmissions was observed (65% vs 78% in MAC vs NoMAC, p=0.145). One-year mortality tended to be higher in MAC patients (19.7% vs 11.3%, p=0.050), with no difference in cardiovascular mortality (15.3% vs 9.2%, p=0.129).
conclusionsMitraClip use in selected patients with moderate or severe MAC is safe, feasible and achieves good clinical and echocardiographic results at one-year follow-up.
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