SynthesisSeminars in oncology nursing2021
Symptom Clusters in Head and Neck Cancer: A Systematic Review and Conceptual Model.
Synthesis in Seminars in oncology nursing, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
33 citing papers in PubMed, 3 syntheses or guidelines pooled it, 36 citations in OpenAlex.
- The Effectiveness of Interventions Based on Symptom Clusters for Symptom Burden and Quality of Life Among Cancer Patients: A Meta-Analysis of Randomized Controlled Trials.Research in nursing & health · 2026Pooled it
- Exploring Symptom Cluster Patterns in Adult Cancer Patients Undergoing Chemotherapy: A Systematic Review.Journal of Korean Academy of Nursing · 2024Pooled it
- Symptom management in adult brain tumours: A literature review.Nursing open · 2023Pooled it
- Changes in postoperative symptom communities and network structure in patients with oral squamous cell carcinoma: A four-time-point study.Asia-Pacific journal of oncology nursing · 2026Article
- Network-derived symptom architecture and simulated leverage points during radiotherapy for oral cancer.Asia-Pacific journal of oncology nursing · 2026Article
- Depressive symptoms and perceived stress in patients with head and neck cancer undergoing intensity-modulated radiation therapy: A longitudinal study.European journal of oncology nursing : the official journal of European Oncology Nursing Society · 2026Article
- A mixed-method study of identifying symptom clusters in adult patients with advanced cancer.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2026Article
- "When symptoms interact and change": longitudinal network analysis of dynamic symptom changes in oral cancer patients.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2026Article
- Symptom Clusters and Related Factors of Late Toxicities in Head and Neck Cancer Survivors After Radiation Therapy: A Cross-Sectional Study.Nursing reports (Pavia, Italy) · 2026Article
- Multidomain predictors of long-term work disability in late survivorship after head and neck cancer.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2026Article
- Article
- Social wellbeing, loneliness, and symptom burden in head and neck cancer survivors: a latent class analysis.Journal of psychosocial oncology · 2026Article
- Identification of symptom clusters and sentinel symptoms in preoperative patients with oral and maxillofacial cancers: A cross-sectional study.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2025Article
- Perioperative symptom cluster characteristics and supportive care needs of sellar tumor patients: a cross-sectional study.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2025Observational
- VEGFA (rs1570360, rs699947, rs3025033, rs2146323, rs3024997) genotypes in patients with laryngeal squamous cell carcinoma.BMC cancer · 2025Article
- An exploration of nursing and Allied Health Professional (AHP)-led post-treatment surveillance and survivorship care for people with head and neck cancer-a scoping review.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2025Article
- Article
- PRO-Based Stratification Improves Model Prediction for Toxicity and Survival of Head and Neck Cancer Patients.IEEE journal of biomedical and health informatics · 2025Article
- Collaborative Filtering for the Imputation of Patient Reported Outcomes.Database and expert systems applications : 35th International Conference, DEXA 2024, Naples, Italy, August 26-28, 2024, Proceedings. Part I. Database and Expert Systems Applications Conference (35th : 2024 : Naples, Italy) · 2024Article
- Quality of life, craniomandibular function, and psychosocial factors related to pain and movement in patients with head and neck cancer.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 2 institutions in 2 countries.
Funding
Abstract
objectiveThe two approaches to symptom-cluster research include grouping symptoms and grouping patients. The objective of this systematic review was to examine the conceptual approaches and methodologies used in symptom-cluster research in patients with head and neck cancer. DATA SOURCES: Articles were retrieved from electronic databases (CINAHL, MEDLINE via Ovid, APA PsycINFO, Scopus, Embase, and Cochrane Central Register of Controlled Trials-CENTRAL), five grey literature portals, and Google Scholar. Seventeen studies met the eligibility criteria. Eight studies grouped symptoms to identify symptom clusters, of which two used qualitative methods. The number of symptom clusters ranged from two to five, and the number of symptoms in a cluster ranged from 2 to 11. Nine studies grouped patients based on their experiences with multiple symptoms. Cluster analysis and factor analysis were most commonly used. Despite variable names and composition of symptom clusters, synthesis revealed three prominent symptom clusters: general, head and neck cancer-specific, and gastrointestinal. Being female and quality of life were significantly associated with high symptom group or cluster severity. Biological mechanisms were sparsely examined.
conclusionSymptom cluster research in head and neck cancer is emerging. Consensus on nomenclature of a symptom cluster will facilitate deduction of core clinically relevant symptom clusters in head and neck cancer. Further research is required on understanding patients' subjective experiences, identifying predictors and outcomes, and underlying mechanisms for symptom clusters. IMPLICATIONS FOR NURSING PRACTICE: Identification of clinically relevant symptom clusters would enable targeted symptom assessment and management strategies, thus improving treatment efficiencies and patient outcomes.
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Registered trials
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