Evidence map›Paper›PMID 34482807›Full record

ArticleBioengineered2021

Genome-wide screening for the G-protein-coupled receptor (GPCR) pathway-related therapeutic gene

Yue Liu, Weiming Lou, Guang Chen, Bing Ding, Jin Kuang, Yize Zhang, Cong Wang, Sainan Duan, Ying Deng, Xiongbing Lu

Open access · goldAbstract read
In one paragraph

Article in Bioengineered, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
0.7field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 9 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

Yue LiuQueen Mary School, Medical Collage of Nanchang University, Nanchang, China.ORCID 0000-0002-7623-4431
Weiming LouInstitute of Translational Medicine, Nanchang University, Nanchang, China.
Guang ChenDepartment of Urology, The Second Affiliated Hospital of Nanchang University, Nanchang, China.
Bing DingDepartment of Urology, The Second Affiliated Hospital of Nanchang University, Nanchang, China.
Jin KuangDepartment of Urology, The Second Affiliated Hospital of Nanchang University, Nanchang, China.
Yize ZhangThe Second Affiliated Hospital of Nanchang University, Nanchang University, Nanchang, Jiangxi Province, China.
Cong WangThe First Affiliated Hospital of Nanchang University, Nanchang University, Jiangxi Province, China.
Sainan DuanThe First Affiliated Hospital of Nanchang University, Nanchang University, Jiangxi Province, China.
Ying DengThe Second Affiliated Hospital of Nanchang University, Nanchang University, Jiangxi Province, China.
Xiongbing LuDepartment of Urology, The Second Affiliated Hospital of Nanchang University, Nanchang, China.
Nanchang University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Bladder cancer is one of the most severe genitourinary cancers, causing high morbidity worldwide. However, the underlying molecular mechanism is not clear, and it is urgent to find target genes for treatment. G-protein-coupled receptors are currently a target of high interest for drug design. Thus, we aimed to identify a target gene-related to G-protein-coupled receptors for therapy. We used The Cancer Genome Atlas (TCGA) and DepMap databases to obtain the expression and clinical data of

Indexed as

RGS ProteinsUrinary Bladder NeoplasmsAza CompoundsCell CycleCell Line, TumorCell ProliferationDatabases, GeneticHumansIndolesPrognosisProtein Kinase InhibitorsSignal TransductionAza CompoundsGSK 1070916IndolesProtein Kinase Inhibitorsregulator of G-protein signalling 19RGS ProteinsBladder cancercell cycleg-protein-coupled receptorgsk1070916rgs19

Identifiers

PMID34482807
PMCPMC8806424
OpenAlexW3198232420

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.