Evidence map›Paper›PMID 34482798›Full record

ArticleBioengineered2021

Downregulation of Salusin-β protects renal tubular epithelial cells against high glucose-induced inflammation, oxidative stress, apoptosis and lipid accumulation via suppressing miR-155-5p.

Hongmei Chen, Genjuan Jin

Abstract read
In one paragraph

Article in Bioengineered, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Hongmei ChenDepartment of Endocrinology and Metabolism, Nantong No.2 People's Hospital, Nantong, Jiangsu Province, China.
Genjuan JinDepartment of Endocrinology, Zhejiang Xiaoshan Hospital, Hangzhou, Zhejiang Province, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Diabetic nephropathy (DN) is the main contributor to the excess mortality for patients suffering from diabetes. Here, C57BL/6 mice received 4 weeks of high-fat diet and intraperitoneal injection of STZ (100 mg/kg). Mice with random blood glucose level ≥16.7 mmol/L and positive urine protein were recognized as successful DN model. To construct an

Indexed as

AnimalsCell LineDiabetic NephropathiesDown-RegulationEpithelial CellsGlucoseHumansInflammationIntercellular Signaling Peptides and ProteinsKidney TubulesLipid MetabolismMiceMice, Inbred C57BLMicroRNAsOxidative StressGlucoseIntercellular Signaling Peptides and ProteinsMicroRNAsMIRN155 microRNA, humanMirn155 microRNA, mouseTOR2A protein, humandiabetic nephropathymiR-155-5prenal tubular epithelial cellsSalusin-β

Identifiers

PMID34482798
PMCPMC8806677

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.