Evidence map›Paper›PMID 34482708›Full record

ArticleJournal of the American Heart Association2021

Proteins as Mediators of the Association Between Diet Quality and Incident Cardiovascular Disease and All-Cause Mortality: The Framingham Heart Study.

Youjin Kim, Sophia Lu, Jennifer E Ho, Shih-Jen Hwang, Chen Yao, Tianxiao Huan, Daniel Levy, Jiantao Ma

Open access · goldAbstract read
In one paragraph

Article in Journal of the American Heart Association, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed, 1 pooled it
3.9field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 1 synthesis or guideline pooled it, 26 citations in OpenAlex.

  1. Pooled it
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  12. Nutritional Epidemiology and Dietary Assessment for Patients With Kidney Disease: A Primer.American journal of kidney diseases : the official journal of the National Kidney Foundation · 2023
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 5 institutions in 1 country.

Youjin KimNutrition Epidemiology and Data Science Friedman School of Nutrition Science and Policy Tufts University Boston MA.ORCID 0000-0002-2192-729X
Sophia LuHealth Sciences Sargent CollegeBoston University Boston MA.
Jennifer E HoDivision of Cardiology Department of Medicine and Cardiovascular Research Center Massachusetts General Hospital Boston MA.ORCID 0000-0002-7987-4768
Shih-Jen HwangPopulation Sciences Branch National Heart, Lung, and Blood InstituteNIH Bethesda MD.ORCID 0000-0002-2129-5704
Chen YaoPopulation Sciences Branch National Heart, Lung, and Blood InstituteNIH Bethesda MD.ORCID 0000-0002-3944-7788
Tianxiao HuanDepartment of Ophthalmology and Visual Sciences University of Massachusetts Medical School Worcester MA.ORCID 0000-0001-5840-9413
Daniel LevyPopulation Sciences Branch National Heart, Lung, and Blood InstituteNIH Bethesda MD.ORCID 0000-0003-1843-8724
Jiantao MaNutrition Epidemiology and Data Science Friedman School of Nutrition Science and Policy Tufts University Boston MA.ORCID 0000-0001-7478-7203
National Heart Lung and Blood Institute · USTufts University · USBoston University · USMassachusetts General Hospital · USUniversity of Massachusetts Chan Medical School · US

Funding

Eicosanoid Profiles as Determinants of HFpEFR01HL140224 · NHLBI · MASSACHUSETTS GENERAL HOSPITAL · PI HO, JENNIFER E · 2018 to 2021
$3.1M
The Association of Metabolic Disease and Pulmonary HypertensionR01HL134893 · NHLBI · MASSACHUSETTS GENERAL HOSPITAL · PI HO, JENNIFER E · 2017 to 2021
$2.9M
Dietary factors, biomarkers, metabolic pathways related to non-alcoholic fatty liver diseaseK22HL135075 · NHLBI · TUFTS UNIVERSITY BOSTON · PI MA, JIANTAO · 2019 to 2021
$747k
THE FRAMINGHAM HEART STUDY-N01HC25195-268025195-268025195N01HC025195 · HC · TRUSTEES OF BOSTON UNIVERSITY · PI WOLF, PHILIP A · 2002 to 2006
–
NHLBI NIH HHS K22 HL135075NHLBI NIH HHS N01 HC025195NHLBI NIH HHS R01 HL134893NHLBI NIH HHS R01 HL140224
6 · The paper itself

Abstract

Background Biological mechanisms underlying the association of a healthy diet with chronic diseases remain unclear. Targeted proteomics may facilitate the understanding of mechanisms linking diet to chronic diseases. Methods and Results We examined 6360 participants (mean age 50 years; 54% women) in the Framingham Heart Study. The associations between diet and 71 cardiovascular disease (CVD)-related proteins were examined using 3 diet quality scores: the Alternate Healthy Eating Index, the modified Mediterranean-style Diet Score, and the modified Dietary Approaches to Stop Hypertension diet score. A mediation analysis was conducted to examine which proteins mediated the associations of diet with incident CVD and all-cause mortality. Thirty of the 71 proteins were associated with at least 1 diet quality score (

Indexed as

Cardiovascular DiseasesDietMortalityChronic DiseaseDietary Approaches To Stop HypertensionDiet, HealthyDiet, MediterraneanFemaleHumansLongitudinal StudiesMaleMiddle AgedProteomicsRisk Factorscardiovascular diseasediet qualitymediatormortalityproteomics

Identifiers

PMID34482708
PMCPMC8649513
OpenAlexW3197775729

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.