ArticleAlzheimer's & dementia : the journal of the Alzheimer's Association2022
Associations among vascular risk factors, neuroimaging biomarkers, and cognition: Preliminary analyses from the Multi-Ethnic Study of Atherosclerosis (MESA).
Article in Alzheimer's & dementia : the journal of the Alzheimer's Association, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers, 1 of them a synthesis that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
35 citing papers in PubMed, 1 synthesis or guideline pooled it, 45 citations in OpenAlex.
- The causative role of amyloidosis in the cardiac complications of Alzheimer's disease: a comprehensive systematic review.The Journal of physiology · 2026Pooled it
- Blood pressure reduction and all-cause dementia in people with uncontrolled hypertension: an open-label, blinded-endpoint, cluster-randomized trial.Nature medicine · 2025Trial
- Association between reproductive history, white matter integrity, and cognition in post-menopausal Latina women from the Boston Latino Aging Study.Journal of clinical and experimental neuropsychology · 2026Observational
- Dissecting Alzheimer's proteomic landscape through NULISA profiling of brain cell-specific extracellular vesicles.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Article
- Evaluation of an in vivo biomarker of arteriolosclerosis (ARTS) and its associations with cognition and multimodal ATN(V) biomarkers in a cardiometabolic-risk enriched community cohort.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Article
- Association of residential neighborhood disadvantage with amyloid PET positivity among cognitively impaired individuals.Alzheimer's & dementia. Behavior & socioeconomics of aging · 2026Article
- Sex differences in the association of vascular risk and APOE Genotype with cognitive decline and dementia: evidence from a U.S. longitudinal study.Lancet regional health. Americas · 2026Article
- Evaluation of an in vivo biomarker of arteriolosclerosis (ARTS) and its associations with cognition and multimodal ATN(V) biomarkers in a cardiometabolic-risk enriched community cohort.medRxiv : the preprint server for health sciences · 2025Article
- Subclinical vascular burden in relation to cognitive decline and impairment: The Multi-Ethnic Study of Atherosclerosis (MESA).Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Observational
- Carotid and regional arterial stiffness and dementia-related imaging biomarkers in the Multi-Ethnic Study of Atherosclerosis (MESA).Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Article
- The cognitive toll of household air pollution: cross-sectional associations between polluting cooking fuel use, cognitive functions and brain MRI in a rural aging population from Karnataka, India.The Lancet regional health. Southeast Asia · 2025Article
- Evaluation of plasma p-tau217 for detecting amyloid pathology in a heterogeneous community-based cohort.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Article
- On the complexity of biomarker-driven diagnoses of Alzheimer's disease.Journal of neuropsychology · 2025Article
- Lifespan cardiometabolic exposures are associated with midlife white matter microstructure: The Bogalusa Heart Study.NeuroImage · 2025Article
- Neuroprotective Effect of Artemisinin in an Animal Model of Alzheimer's Disease.Current medicinal chemistry · 2025Article
- Subclinical vascular risk composites and dementia imaging biomarkers 17-20 years later in the Multi-Ethnic Study of Atherosclerosis (MESA).Cerebral circulation - cognition and behavior · 2025Article
- Identifying modifiable factors and their joint effect on brain health: an exposome-wide association study.GeroScience · 2024Article
- Associations among plasma, MRI, and amyloid PET biomarkers of Alzheimer's disease and related dementias and the impact of health-related comorbidities in a community-dwelling cohort.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2024Article
- Subclinical vascular composites predict clinical cardiovascular disease, stroke, and dementia: The Multi-Ethnic Study of Atherosclerosis (MESA).Atherosclerosis · 2024Article
- Disparate Dementia Risk Factors Are Associated with Cognitive Impairment and Rates of Decline in African Americans.Annals of neurology · 2024Article
Corrections and comments
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Authors and funding
14 authors at 1 institution in 1 country.
Funding
Abstract
introductionLittle is known about how antecedent vascular risk factor (VRF) profiles impact late-life brain health.
methodsWe examined baseline VRFs, and cognitive testing and neuroimaging measures (β-amyloid [Aβ] PET, MRI) in a diverse longitudinal cohort (N = 159; 50% African-American, 50% White) from Wake Forest's Multi-Ethnic Study of Atherosclerosis Core.
resultsAfrican-Americans exhibited greater baseline Cardiovascular Risk Factors, Aging, and Incidence of Dementia (CAIDE), Framingham stroke risk profile (FSRP), and atherosclerotic cardiovascular disease risk estimate (ASCVD) scores than Whites. We observed no significant racial differences in Aβ positivity, cortical thickness, or white matter hyperintensity (WMH) volume. Higher baseline VRF scores were associated with lower cortical thickness and greater WMH volume, and FSRP and CAIDE were associated with Aβ. Aβ was cross-sectionally associated with cognition, and all imaging biomarkers were associated with greater 6-year cognitive decline. DISCUSSION: Results suggest the convergence of multiple vascular and Alzheimer's processes underlying neurodegeneration and cognitive decline.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.